Document Detail

The importance of reducing heart rate in cardiovascular diseases: effects of Ivabradine.
MedLine Citation:
PMID:  22193347     Owner:  NLM     Status:  In-Data-Review    
Heart rate is a major determinant of cardiac output, myocardial oxygen consumption and coronary blood flow under physiological and pathological conditions. Experimental and clinical data have demonstrated that heart rate reduction is the main mechanism for reducing ischemia, improving left ventricular function, decreasing the risk of plaque rupture and post myocardial infarction mortality. Nowadays betablockers are the best class of drugs that can lower heart rate in patients with cardiovascular diseases, but sometimes their use is limited by some contraindications. Ivabradine is a new drug that reduces the firing rate of pacemaker cells in the sinoatrial node through a different mechanism with respect to betablockers. The purpose of this review is to investigate the main trials that support Ivabradine adoption in clinical practice.
E Vizzardi; I Bonadei; A D'Aloia; F Del Magro; B Piovanelli; L Bontempi; A Curnis; L Dei Cas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva medica     Volume:  102     ISSN:  0026-4806     ISO Abbreviation:  Minerva Med.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400732     Medline TA:  Minerva Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  IM    
Section of Cardiovascular diseases, Department of Experimental and Applied MedicineUniversity of Study of Brescia, Brescia, Italy -
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