| The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts. | |
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MedLine Citation:
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PMID: 17824958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Grape (Vitis vinifera) and pine (Pinus pinaster) bark extracts are widely used as nutritional supplements. Procyanidin-rich fractions from grape and pine bark extract showing different mean degrees of polymerization, percentage of galloylation (percentage of gallate esters) and reactive oxygen species-scavenging capacity were tested on HT29 human colon cancer cells. We observed that the most efficient fractions in inhibiting cell proliferation, arresting the cell cycle in G(2) phase and inducing apoptosis were the grape fractions with the highest percentage of galloylation and mean degree of polymerization. Additionally, the antiproliferative effects of grape fractions were consistent with their oxygen radical-scavenging capacity and their ability to trigger DNA condensation-fragmentation. |
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Authors:
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D Lizarraga; C Lozano; J J Briedé; J H van Delft; S Touriño; J J Centelles; J L Torres; M Cascante |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The FEBS journal Volume: 274 ISSN: 1742-464X ISO Abbreviation: FEBS J. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-10 Completed Date: 2007-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101229646 Medline TA: FEBS J Country: England |
Other Details:
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Languages: eng Pagination: 4802-11 Citation Subset: IM |
Affiliation:
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Biochemistry and Molecular Biology Department, Biology Faculty, University of Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Biflavonoids / chemistry* Biopolymers / chemistry Catechin / chemistry* Cell Cycle / drug effects* Cell Line Cell Proliferation / drug effects HT29 Cells Humans Molecular Structure Pinus / chemistry* Plant Bark / chemistry Proanthocyanidins / chemistry* Rats Tissue Extracts / chemistry*, pharmacology* Vitis / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Biflavonoids; 0/Biopolymers; 0/Proanthocyanidins; 0/Tissue Extracts; 154-23-4/Catechin; 4852-22-6/procyanidin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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