Document Detail

The importance of physicochemical swelling in cartilage illustrated with a model hydrogel system.
MedLine Citation:
PMID:  9720901     Owner:  NLM     Status:  MEDLINE    
The physicochemically derived swelling stress in articular cartilage plays a crucial role in determining the pattern of stress sharing between the exudable fluid and the 'solid' components comprising its matrix. This pattern of stress sharing in turn influences the manner in which cartilage consolidates or deforms in compression via the outflow of fluid. Synthetic hydrogels exposed to a variety of cationic blocking solutions provide simplified model systems for exploring quantitatively the influence of the intrinsic swelling parameter on consolidation behaviour, thus yielding further insights into the fundamental parameters controlling the biomechanical properties of complex tissues such as articular cartilage.
N D Broom; A Oloyede
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomaterials     Volume:  19     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-24     Completed Date:  1998-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1179-88     Citation Subset:  IM    
Department of Mechanical Engineering, University of Auckland, New Zealand.
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MeSH Terms
Acrylic Resins / chemistry
Biocompatible Materials*
Cartilage, Articular / chemistry,  physiology*
Glycosaminoglycans / chemistry
Models, Biological
Osmolar Concentration
Reg. No./Substance:
0/Acrylic Resins; 0/Biocompatible Materials; 0/Glycosaminoglycans; 0/Hydrogels; 9003-01-4/carbopol 940

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