| The importance of nasal provocation test in the diagnosis of natural rubber latex allergy. | |
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MedLine Citation:
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PMID: 19170669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most studies regarding natural rubber latex (NRL) allergy have concentrated on the prevalence using skin prick test (SPT) and specific IgE assay. The objective of this study is to examine the target organ (skin, nasal mucosa) responses in patients with positive SPT to NRL using the nasal provocation test (NPT) and glove use test (GUT). METHODS: Four thousand four hundred and twenty patients presented to our polyclinic between July 2003 and January 2007 were evaluated. One thousand six hundred and ninety-nine patients had positive SPT to one or more allergens (NRL and other inhaler allergens). Twenty-nine patients with positive SPT to NRL comprised the NRL sensitive group (group 1). Thirty-five randomized patients with positive SPT to an inhaler allergen other than NRL and negative NRL-specific IgE comprised atopic control group (group 2). Thirty healthy individuals who had no allergic diseases and had negative SPT and NRL-specific IgE comprised the healthy control group (group 3). RESULTS: The lowest NRL allergen concentration leading to NPT positiveness was 0.05 microg/mL. NPT was negative in groups 2 and 3. NPT was found to have a sensitivity of 96%, specificity of 100%, negative predictive value of 98% and positive predictive value of 100%. GUT was found to have a sensitivity of 81%, specificity of 90%, negative predictive value of 75% and positive predictive value of 93%. CONCLUSIONS: Nasal provocation test was successfully used for the first time in the diagnosis of NRL allergy. NPT is a more sensitive method as compared to GUT. |
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Authors:
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M Unsel; N Mete; O Ardeniz; S Göksel; R Ersoy; A Sin; O Gulbahar; A Kokuludag |
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Publication Detail:
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Type: Journal Article Date: 2009-01-19 |
Journal Detail:
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Title: Allergy Volume: 64 ISSN: 1398-9995 ISO Abbreviation: Allergy Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-20 Completed Date: 2009-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: Denmark |
Other Details:
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Languages: eng Pagination: 862-7 Citation Subset: IM |
Affiliation:
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Ege University Medical Faculty, Internal Medicine, Division of Allergy and Clinical Immunology, Izmir, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Forced Expiratory Volume Gloves, Protective / adverse effects Humans Immunoglobulin E / blood Latex Hypersensitivity / diagnosis* Male Middle Aged Nasal Provocation Tests / methods* Predictive Value of Tests Skin Tests |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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