Document Detail

The importance of hemodynamic considerations in essential hypertension.
MedLine Citation:
PMID:  3293403     Owner:  NLM     Status:  MEDLINE    
Hypertension is a major risk factor for cardiovascular morbidity and mortality. Antihypertensive therapy consistently reduces complications from stroke and congestive heart failure, whereas benefits from the treatment of ischemic heart disease events are variable. Several plausible explanations, including hemodynamic hypotheses, have been put forth to account for the failure of treatment to more favorably influence mortality from ischemic heart disease. The effect of hypertension on coronary heart disease is probably much more complex than a simple elevation of arterial pressure. Some of these complexities include the potential separate risks of high total peripheral resistance, high cardiac output, increased myocardial power that reflects pressure times flow, and several structural and functional vascular changes. These factors may act in concert to unfavorably alter the balance between myocardial oxygen supply and demand. Several of these factors will be highlighted in an attempt to offer alternative or adjunctive pathophysiologic examinations for the high-risk subgroups of obesity and the failure of antihypertensive therapy to normalize the rate of coronary heart disease events.
B Egan; R Schmouder
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American heart journal     Volume:  116     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-08-25     Completed Date:  1988-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  594-9     Citation Subset:  AIM; IM    
Division of Hypertension, University of Michigan Medical Center, Ann Arbor 48109-0356.
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MeSH Terms
Blood Pressure
Cardiac Output
Hypertension / mortality,  physiopathology*
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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