| The importance of hemodynamic considerations in essential hypertension. | |
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MedLine Citation:
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PMID: 3293403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is a major risk factor for cardiovascular morbidity and mortality. Antihypertensive therapy consistently reduces complications from stroke and congestive heart failure, whereas benefits from the treatment of ischemic heart disease events are variable. Several plausible explanations, including hemodynamic hypotheses, have been put forth to account for the failure of treatment to more favorably influence mortality from ischemic heart disease. The effect of hypertension on coronary heart disease is probably much more complex than a simple elevation of arterial pressure. Some of these complexities include the potential separate risks of high total peripheral resistance, high cardiac output, increased myocardial power that reflects pressure times flow, and several structural and functional vascular changes. These factors may act in concert to unfavorably alter the balance between myocardial oxygen supply and demand. Several of these factors will be highlighted in an attempt to offer alternative or adjunctive pathophysiologic examinations for the high-risk subgroups of obesity and the failure of antihypertensive therapy to normalize the rate of coronary heart disease events. |
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Authors:
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B Egan; R Schmouder |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American heart journal Volume: 116 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-08-25 Completed Date: 1988-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 594-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Hypertension, University of Michigan Medical Center, Ann Arbor 48109-0356. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Cardiac Output Hemodynamics* Humans Hypertension / mortality, physiopathology* Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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