Document Detail


The importance of a genetic evaluation of prospective ovum donors: a study of family history and genetic carrier testing.
MedLine Citation:
PMID:  22010526     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To determine the percentage of potential ovum donors who have an increased risk for fetal harm.
STUDY DESIGN: Couples using an ovum donor to conceive a pregnancy are expecting to select someone who poses a low genetic risk to their offspring. Currently, most genetic carrier screening of these donors is performed at the discretion of the fertility center. This investigation involves a review of family history and genetic carrier test results of oocyte donor candidates.
RESULTS: A total of 210 (22.1%) of 950 potential oocyte donors had at least one fetal risk factor based on family history. Of 244 prospective donors who had genetic testing, 15 (6.1%) were found to be carriers of hereditary diseases that could pose an increased risk to a fetus.
CONCLUSION: A genetic assessment is a critical step in the evaluation of prospective oocyte donors, because almost one quarter of donors had a family history of a disease that could pose an increased fetal risk. Disclosure of ovum donor carrier status and, when applicable, testing of partners is required before accepting a potential ovum donor in an infertility program.
Authors:
Joyce E Basile; Alan E Donnenfeld
Related Documents :
21790636 - Partial d phenotypes and genotypes in the chinese population.
21674006 - Genome-wide association study of schizophrenia in japanese population.
22160516 - The functional slc11a1 gene polymorphisms are associated with sarcoidosis in turkish po...
21739446 - Antiviral combination therapy with peginterferon and ribavirin does not induce a therap...
17585316 - Fgfr3 mutations in seborrheic keratoses are already present in flat lesions and associa...
9654006 - Genetic requirement of epidermal and female germ line cells in drosophila in the light ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  56     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-20     Citation Subset:  IM    
Affiliation:
Genzyme Genetics, 833 Chestnut Street, Suite 1250, Philadelphia, PA 19107, USA. joyce.basile@genzymegenetics.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rescue intracytoplasmic sperm injection: a prospective randomized study.
Next Document:  Maternal-neonatal outcome with Staphylococcus aureus rectovaginal colonization.