Document Detail

The importance of distributed sampling in blocked functional magnetic resonance imaging designs.
MedLine Citation:
PMID:  12414260     Owner:  NLM     Status:  MEDLINE    
In this study we demonstrate the importance of distributed sampling of peristimulus time in blocked design fMRI studies. Distributed sampling ensures all the components of an event-related hemodynamic response are sampled and avoids the bias incurred when stimulus presentation is time-locked to data acquisition. We found that differences in the temporal offset between stimulus presentation and data acquisition had a significant effect on some language-related activations. These effects, induced by simply shifting stimulus presentation by a fraction of the interscan interval, suggest that fixed sampling does indeed bias estimated responses, even in blocked designs.
Dick J Veltman; Andrea Mechelli; Karl J Friston; Cathy J Price
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  NeuroImage     Volume:  17     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-02-13     Revised Date:  2010-05-20    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1203-6     Citation Subset:  IM    
PET Center, Vrije Universiteit Medical Center. De Boelelaan 1117, Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Attention / physiology*
Brain Mapping / methods*
Cerebral Cortex / physiology*
Dominance, Cerebral / physiology
Hemodynamics / physiology
Image Processing, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Magnetic Resonance Imaging / methods*
Oxygen / blood
Reference Values
Grant Support
051067//Wellcome Trust
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Statistical parametric mapping of (99m)Tc-HMPAO-SPECT images for the diagnosis of Alzheimer's diseas...
Next Document:  The human prefrontal and parietal association cortices are involved in NO-GO performances: an event-...