Document Detail


The importance of distributed sampling in blocked functional magnetic resonance imaging designs.
MedLine Citation:
PMID:  12414260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we demonstrate the importance of distributed sampling of peristimulus time in blocked design fMRI studies. Distributed sampling ensures all the components of an event-related hemodynamic response are sampled and avoids the bias incurred when stimulus presentation is time-locked to data acquisition. We found that differences in the temporal offset between stimulus presentation and data acquisition had a significant effect on some language-related activations. These effects, induced by simply shifting stimulus presentation by a fraction of the interscan interval, suggest that fixed sampling does indeed bias estimated responses, even in blocked designs.
Authors:
Dick J Veltman; Andrea Mechelli; Karl J Friston; Cathy J Price
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  NeuroImage     Volume:  17     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-02-13     Revised Date:  2010-05-20    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1203-6     Citation Subset:  IM    
Affiliation:
PET Center, Vrije Universiteit Medical Center. De Boelelaan 1117, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Attention / physiology*
Brain Mapping / methods*
Cerebral Cortex / physiology*
Dominance, Cerebral / physiology
Female
Hemodynamics / physiology
Humans
Image Processing, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Magnetic Resonance Imaging / methods*
Male
Oxygen / blood
Reading*
Reference Values
Grant Support
ID/Acronym/Agency:
051067//Wellcome Trust
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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