Document Detail

The importance of developmental timing in cortical specification.
MedLine Citation:
PMID:  8087537     Owner:  NLM     Status:  MEDLINE    
Environmental control of gene expression can occur early or late during development, and this is relevant to understanding species differences in cortical specification. Experiments in the developing visual system of the primate show that the areal limits of striate cortex are specified by the thalamic inputs, so that afferent specification of cortex appears as a general feature of mammalian development. Primates differ from nonprimates in that thalamic afferents control very early stages of corticogenesis when symmetrical cell division is forming the pool of striate neuron precursors. Other cortical features are specified much later in primates than in nonprimates. We speculate that the early specification of certain features and the late specification of others contribute to the sophistication of the cerebral cortex characteristic of primates.
H Kennedy; C Dehay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Perspectives on developmental neurobiology     Volume:  1     ISSN:  1064-0517     ISO Abbreviation:  Perspect Dev Neurobiol     Publication Date:  1993  
Date Detail:
Created Date:  1994-10-14     Completed Date:  1994-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9417971     Medline TA:  Perspect Dev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
INSERM U371, Cerveau et Vision, Bron, France.
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MeSH Terms
Afferent Pathways / physiology
Anophthalmos / physiopathology
Cell Differentiation
Cerebral Cortex / embryology*
Embryonic and Fetal Development
Eye Enucleation
Gene Expression Regulation
Primates / embryology,  growth & development
Rodentia / embryology
Species Specificity
Thalamus / physiology
Time Factors
Visual Cortex / embryology,  growth & development

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