Document Detail

The importance of dedifferentiation in recurrent acinic cell carcinoma.
MedLine Citation:
PMID:  11535145     Owner:  NLM     Status:  MEDLINE    
The biological activity of acinic cell carcinoma is uncertain. Histological dedifferentiation is one possible reason for recurrent disease, and this study was undertaken to assess its importance in acinic cell carcinoma. The initial and recurrent specimens from five patients with acinic cell carcinoma were assessed histologically and using flow cytometry, AgNOR estimation and morphometric analysis for evidence of dedifferentiation. No objective evidence of a change in biological aggressiveness in recurrent acinic cell carcinoma was identified. In this limited series of a rare salivary gland tumour, it would appear that factors other than dedifferentiation, such as close/involved margins, histological type and stage have a more meaningful effect on the likelihood of recurrence and prognosis.
C I Timon; I Dardick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  115     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-05     Completed Date:  2001-09-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  639-44     Citation Subset:  AIM; IM    
Department of Orolaryngology, Head and Neck Surgery, St James's Hospital, Dublin, Ireland.
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MeSH Terms
Carcinoma, Acinar Cell / genetics,  pathology*
Coloring Agents
Data Interpretation, Statistical
Flow Cytometry
Mitotic Index
Neoplasm Recurrence, Local / pathology*
Nucleolus Organizer Region / ultrastructure
Salivary Gland Neoplasms / genetics,  pathology*
Silver Staining
Reg. No./Substance:
0/Coloring Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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