Document Detail

The importance of central venous catheter removal in patients with candidaemia: time to rethink our practice?
MedLine Citation:
PMID:  18005175     Owner:  NLM     Status:  MEDLINE    
The issue of central venous catheter (CVC) removal in adult patients with candidaemia remains controversial. Although removal of CVCs has been advocated as an adjunctive strategy for treating patients with candidaemia, most studies have failed to control for important variables, e.g., the severity of illness and persistence of neutropenia. Multivariate analysis has failed to identify a significant effect of CVC removal on the prognosis for patients with candidaemia. A properly designed randomised trial that controls for confounding variables is necessary to clarify the importance of CVC removal in such patients. Until this evidence is available, systematic removal of all CVCs in these patients seems not to be justified.
A C Pasqualotto; L C Severo
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-11-13
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  14     ISSN:  1198-743X     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  2-4     Citation Subset:  IM    
School of Medicine, University of Manchester, Manchester, UK.
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MeSH Terms
Candidiasis / therapy*
Catheterization, Central Venous / adverse effects*
Fungemia / therapy*
Patient Care / methods*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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