Document Detail


The importance of catch-up growth after early malnutrition for the programming of obesity in male rat.
MedLine Citation:
PMID:  16988075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate whether catch-up growth after maternal malnutrition would favor the development of obesity in adulthood. RESEARCH METHODS AND PROCEDURES: Pregnant rats were submitted to protein or calorie restriction during the course of gestation. During lactation, pups were protein-restricted, normally fed, or overfed [reduced litter size, control (C) diet]. At weaning, rats were transferred to chow or to a hypercaloric diet (HCD) known to induce obesity. Body weight, food intake, blood parameters, glucose tolerance, adipocyte cellularity, and adipose factors contributing to cardiovascular disease development were measured. RESULTS: Protein and calorie restriction during gestation led to growth retardation at birth. If malnutrition was prolonged throughout lactation, adult body weight was permanently reduced. However, growth-retarded offspring overfed during the suckling period underwent a rapid catch-up growth and became heavier than the normally fed Cs. Offspring of calorie-restricted rats gained more weight than those of dams fed protein-restricted diet. Feeding an HCD postnatally amplified the effect of calorie restriction, and offspring that underwent catch-up growth became more obese than Cs. The HCD was associated with hyperphagia, hyperglycemia, hyperinsulinemia, glucose intolerance, insulin resistance, and adipocyte hypertrophy. The magnitude of effects varied depending on the type and the timing of early malnutrition. The expression of genes encoding factors implicated in cardiovascular disease was also modulated differently by early malnutrition and adult obesity. DISCUSSION: Catch-up growth immediately after early malnutrition should be a key point for the programming of obesity.
Authors:
Florence Bieswal; Marie-Thérèse Ahn; Brigitte Reusens; Paul Holvoet; Martine Raes; William D Rees; Claude Remacle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  14     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-21     Completed Date:  2006-10-30     Revised Date:  2008-01-21    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1330-43     Citation Subset:  IM    
Affiliation:
Laboratory of Cell Biology, University of Louvain, Louvain-la-Neuve, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / cytology,  metabolism
Adiponectin / genetics
Adipose Tissue / cytology,  metabolism
Angiotensinogen / genetics
Animals
Animals, Newborn
Body Weight / physiology*
Diet
Eating / physiology
Female
Leptin / blood
Litter Size
Male
Obesity / blood,  etiology,  physiopathology*
Plasminogen Activator Inhibitor 1 / genetics
Pregnancy
Prenatal Exposure Delayed Effects*
Protein-Energy Malnutrition / physiopathology*
RNA, Messenger / genetics,  metabolism
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Leptin; 0/Plasminogen Activator Inhibitor 1; 0/RNA, Messenger; 0/Triglycerides; 11002-13-4/Angiotensinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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