Document Detail


The implications of alternative splicing in the ENCODE protein complement.
MedLine Citation:
PMID:  17372197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional complexity. Here, we carry out a detailed study of the alternatively spliced gene products annotated in the ENCODE pilot project. We find that alternative splicing in human genes is more frequent than has commonly been suggested, and we demonstrate that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts. For the vast majority of these alternative isoforms, little evidence exists to suggest they have a role as functional proteins, and it seems unlikely that the spectrum of conventional enzymatic or structural functions can be substantially extended through alternative splicing.
Authors:
Michael L Tress; Pier Luigi Martelli; Adam Frankish; Gabrielle A Reeves; Jan Jaap Wesselink; Corin Yeats; Páll Isólfur Olason; Mario Albrecht; Hedi Hegyi; Alejandro Giorgetti; Domenico Raimondo; Julien Lagarde; Roman A Laskowski; Gonzalo López; Michael I Sadowski; James D Watson; Piero Fariselli; Ivan Rossi; Alinda Nagy; Wang Kai; Zenia Størling; Massimiliano Orsini; Yassen Assenov; Hagen Blankenburg; Carola Huthmacher; Fidel Ramírez; Andreas Schlicker; France Denoeud; Phil Jones; Samuel Kerrien; Sandra Orchard; Stylianos E Antonarakis; Alexandre Reymond; Ewan Birney; Søren Brunak; Rita Casadio; Roderic Guigo; Jennifer Harrow; Henning Hermjakob; David T Jones; Thomas Lengauer; Christine A Orengo; László Patthy; Janet M Thornton; Anna Tramontano; Alfonso Valencia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-19
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  104     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-28     Completed Date:  2007-05-14     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5495-500     Citation Subset:  IM    
Affiliation:
Structural Computational Biology Programme, Spanish National Cancer Research Centre, E-28029 Madrid, Spain. mtress@cnio.es
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MeSH Terms
Descriptor/Qualifier:
Alternative Splicing*
Databases, Genetic
Gene Expression Regulation
Genome, Human
Humans
Internet
Models, Molecular
Protein Conformation
Protein Isoforms
Protein Sorting Signals
Protein Structure, Tertiary
Proteins / chemistry
RNA Precursors*
RNA Splicing
Grant Support
ID/Acronym/Agency:
062023//Wellcome Trust; 077198//Wellcome Trust
Chemical
Reg. No./Substance:
0/Protein Isoforms; 0/Protein Sorting Signals; 0/Proteins; 0/RNA Precursors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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