| An impending crisis in the provision of histopathology expertise for mouse functional genomics. | |
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MedLine Citation:
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PMID: 19016567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The generation of new mouse models of human disease is accelerating rapidly, due to the completion of whole-genome sequencing efforts and technological advances in the manipulation of the mouse genome. We sought to investigate manpower issues in the provision of histopathology expertise for mouse functional genomics and compared this to the perceived demand from principal investigators (PIs). Through the European Commission (EC)-funded PRIME pathology training initiative, two questionnaires were devised to collect information from pathologists and EC-funded PIs on the current provision of mouse histopathology expertise in Europe and the demands for this service. We find that pathological analysis is being performed almost exclusively by professionally qualified pathologists, generally employed in clinical diagnostic posts, where the work is undertaken as collaboration outside of their contractual commitments but without previous training in veterinary or comparative pathology. The results indicate that there is a lack of both trainees and provision of specialist training in this field. Unsurprisingly, the availability of diagnostic expertise and advice falls far short of the number of genetically engineered mice (GEM) being generated for analysis. We analyse these results with reference to previous studies and discuss solutions for the future recruitment, training and funding for pathologists in mouse functional genomics in Europe. |
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Authors:
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M V Warren; M L Studley; P Dubus; L Fiette; B Rozell; L Quintanilla-Martinez; M Raspa; M Breuer; J-Y Song; H Gates; S D M Brown; P N Schofield |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pathology Volume: 217 ISSN: 1096-9896 ISO Abbreviation: J. Pathol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
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Languages: eng Pagination: 4-13 Citation Subset: IM |
Affiliation:
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Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. mvw@pathologydiagnostics.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clinical Competence Disease Models, Animal* Europe Genomics / manpower*, standards, statistics & numerical data Mice Pathology, Veterinary / manpower*, standards, statistics & numerical data Personnel Selection / statistics & numerical data Questionnaires Workload / statistics & numerical data |
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