Document Detail


Is impairment in set-shifting specific to frontal-lobe dysfunction? Evidence from patients with frontal-lobe or temporal-lobe epilepsy.
MedLine Citation:
PMID:  16209428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Frontal-lobe epilepsy (FLE), temporal-lobe epilepsy (TLE), and matched-control subjects were administered the Trail Making Test (TMT) of the Delis-Kaplan Executive Function System (D-KEFS; Delis et al., 2001), which assesses set-shifting on a visuomotor sequencing task. Results indicated that patients with FLE were impaired in both speed and accuracy on the switching condition relative to patients with TLE and controls. The two patient groups did not differ from controls on the four baseline conditions of the test, which assess visual scanning, motor speed, number sequencing, and letter sequencing. In addition, seizure-related variables (i.e., age of seizure onset, duration of epilepsy, and seizure frequency) failed to correlate with set-shifting performance in patients with FLE. These results suggest that patients with FLE can be reliably distinguished from those with TLE and control subjects on set-shifting as measured by the DKEFS TMT.
Authors:
Carrie R McDonald; Dean C Delis; Marc A Norman; Evelyn S Tecoma; Vicente I Iragui-Madozi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  11     ISSN:  1355-6177     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-10-07     Completed Date:  2005-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  477-81     Citation Subset:  IM    
Affiliation:
Psychology Service (116B) Delis Lab, Veterans Administration San Diego Healthcare System, 3350 La Jolla Village Drive, La Jolla, CA 92611, USA. camcdonald@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Case-Control Studies
Demography
Epilepsy, Frontal Lobe / physiopathology*
Epilepsy, Temporal Lobe / physiopathology*
Female
Functional Laterality / physiology
Humans
Male
Mental Processes / physiology*
Middle Aged
Psychomotor Performance / physiology*
Reaction Time / physiology
Trail Making Test / statistics & numerical data
Grant Support
ID/Acronym/Agency:
T32-MH18399/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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