| The impaired flow reserve capacity of penetrating intramyocardial coronary arteries in apical hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 15682049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Coronary flow reserve (CFR) capacity of penetrating intramyocardial coronary artery (PICA) in apical hypertrophic (AH) cardiomyopathy has not been studied yet. METHODS: We studied 65 patients with normal coronary angiogram results (mean age 56 +/- 10 years; 33 men, 32 women). Of these, 30 were normotensive without any left ventricular hypertrophy (control group), 24 had hypertension (HTN) without any left ventricular hypertrophy (HTN group), and 11 had AH cardiomyopathy (AH group). PICA-CFR and PICA-width ratio were calculated after the intravenous infusion of adenosine (140 microg/kg/min) just beneath the apical impulse window at a depth of 3 to 5 cm by using high-frequency transthoracic Doppler echocardiography. RESULTS: PICA-CFR was successfully measured in 59 (90.8%) of 65 patients. PICA-CFR was 1.65 +/- 0.49 in AH group, 2.50 +/- 0.77 in HTN group, and 2.42 +/- 0.73 in control group ( P < .005 vs HTN and control). PICA-width ratio was 1.45 +/- 0.42 in AH group, 2.14 +/- 0.72 in HTN group, and 1.81 +/- 0.55 in control group ( P = .025 vs HTN and control). PICA-CFR was closely related to width-ratio of PICA ( r = 0.448, P = .002). Conclusion PICA in AH has higher resting diastolic velocity, wider diameter, and impaired CFR compared with nonhypertrophied myocardium. |
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Authors:
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Ho-Joong Youn; Jong-Min Lee; Chul-Soo Park; Sang-Hyun Ihm; Eun-Joo Cho; Hae-Ok Jung; Hui-Kyung Jeon; Yong-Seog Oh; Wook-Sung Chung; Jae-Hyung Kim; Kyu-Bo Choi; Soon-Jo Hong |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 18 ISSN: 0894-7317 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-31 Completed Date: 2006-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 128-32 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, College of Medicine, The Catholic University of Korea, No. 62 Yoido-dong, Young-dungpo-ku, St. Mary's Hospital, Seoul 150-713, Korea. younhj@catholic.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Flow Velocity Cardiomyopathy, Hypertrophic / physiopathology*, ultrasonography* Coronary Angiography Coronary Circulation* Coronary Vessels / physiopathology*, ultrasonography Echocardiography, Doppler Female Humans Hypertension / physiopathology, ultrasonography Hypertrophy, Left Ventricular / physiopathology, ultrasonography Male Middle Aged Myocardial Contraction Myocardium / pathology Observer Variation Prospective Studies |
| Comments/Corrections | |
Comment In:
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J Am Soc Echocardiogr. 2005 Dec;18(12):1464-6
[PMID:
16376783
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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