Document Detail

The impaired flow reserve capacity of penetrating intramyocardial coronary arteries in apical hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  15682049     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coronary flow reserve (CFR) capacity of penetrating intramyocardial coronary artery (PICA) in apical hypertrophic (AH) cardiomyopathy has not been studied yet. METHODS: We studied 65 patients with normal coronary angiogram results (mean age 56 +/- 10 years; 33 men, 32 women). Of these, 30 were normotensive without any left ventricular hypertrophy (control group), 24 had hypertension (HTN) without any left ventricular hypertrophy (HTN group), and 11 had AH cardiomyopathy (AH group). PICA-CFR and PICA-width ratio were calculated after the intravenous infusion of adenosine (140 microg/kg/min) just beneath the apical impulse window at a depth of 3 to 5 cm by using high-frequency transthoracic Doppler echocardiography. RESULTS: PICA-CFR was successfully measured in 59 (90.8%) of 65 patients. PICA-CFR was 1.65 +/- 0.49 in AH group, 2.50 +/- 0.77 in HTN group, and 2.42 +/- 0.73 in control group ( P < .005 vs HTN and control). PICA-width ratio was 1.45 +/- 0.42 in AH group, 2.14 +/- 0.72 in HTN group, and 1.81 +/- 0.55 in control group ( P = .025 vs HTN and control). PICA-CFR was closely related to width-ratio of PICA ( r = 0.448, P = .002). Conclusion PICA in AH has higher resting diastolic velocity, wider diameter, and impaired CFR compared with nonhypertrophied myocardium.
Ho-Joong Youn; Jong-Min Lee; Chul-Soo Park; Sang-Hyun Ihm; Eun-Joo Cho; Hae-Ok Jung; Hui-Kyung Jeon; Yong-Seog Oh; Wook-Sung Chung; Jae-Hyung Kim; Kyu-Bo Choi; Soon-Jo Hong
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  18     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2006-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-32     Citation Subset:  IM    
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, No. 62 Yoido-dong, Young-dungpo-ku, St. Mary's Hospital, Seoul 150-713, Korea.
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MeSH Terms
Blood Flow Velocity
Cardiomyopathy, Hypertrophic / physiopathology*,  ultrasonography*
Coronary Angiography
Coronary Circulation*
Coronary Vessels / physiopathology*,  ultrasonography
Echocardiography, Doppler
Hypertension / physiopathology,  ultrasonography
Hypertrophy, Left Ventricular / physiopathology,  ultrasonography
Middle Aged
Myocardial Contraction
Myocardium / pathology
Observer Variation
Prospective Studies
Comment In:
J Am Soc Echocardiogr. 2005 Dec;18(12):1464-6   [PMID:  16376783 ]

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