| The impaired fibrinolytic capacity in hypertension is unaffected by acute blood pressure lowering. | |
| | |
MedLine Citation:
|
PMID: 21614456 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The endogenous fibrinolytic system and the ability of the endothelium to release tissue-plasminogen activator (t-PA) play a pivotal role to protect humans from atherothrombotic events. We have recently reported that the decreased capacity for t-PA release in hypertension is restored with chronic blood pressure lowering. Thus, we explored if acute blood pressure lowering has the same effect. The capacity for acute t-PA release was investigated in the perfused-forearm model during stimulation by intra-arterial substance P 8 pmol/min in hypertensive subjects. The procedure was then repeated during acute blood pressure lowering (n = 9) induced by sodium nitroprusside (SNP) infusion or during placebo infusion (n = 3). SNP lowered mean arterial pressure from 108.6 (2.6) to 83.0 (2.6) (mean and SEM) mmHg (P < 0.001). Substance P induced significant increase in t-PA release during both high- and low-pressure conditions (P < 0.01, ANOVA). Peak t-PA release rate was 199 (77) and 167 (41) (mean and SEM) ng/min/l tissue, and accumulated t-PA release was 2,395 (750) and 2,394 (473) ng, during high- and low-pressure conditions, respectively. t-PA release and hemodynamic responses were almost identical during high- and low-pressure conditions (P = ns, for all). Acute blood pressure lowering does not restore stimulated t-PA release from the endothelium in hypertensive subjects. These findings are in contrast to previously described effects of chronic blood pressure treatment. Although data need to be confirmed in a larger study, they suggest that high blood pressure decreases the cellular t-PA pool rather than interferes with release mechanisms of the protein. |
| | |
Authors:
|
Wilhelm Ridderstråle; Ott Saluveer; Maria Carlström; Sverker Jern; Thórdís J Hrafnkelsdóttir |
Related Documents
:
|
2271366 - A comparison of dilevalol and placebo in the management of isolated systolic hypertensi... 343006 - Prazosin in hypertension. part ii. effects of the initial dose. 2994986 - Enalapril in essential hypertension. 6094076 - Blood pressure, plasma volume, and catecholamine levels during enalapril therapy in bla... 12439526 - Use of automated home blood pressure monitoring in pregnancy: is it safe? 12428966 - Sorption and vapor transmission properties of uncompressed and compressed microcellular... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-26 |
Journal Detail:
|
Title: Journal of thrombosis and thrombolysis Volume: - ISSN: 1573-742X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
The Wallenberg Laboratory for Cardiovascular Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Can resistance to aspirin be reversed after an additional dose?
Next Document: Heart rate and functional impairment are predictors of outcome in heart failure patients in the real...