| The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes. | |
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MedLine Citation:
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PMID: 15163474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of the present study was to assess the impact of Mg + Zn, Vitamins C + E, and combination of these micronutrients on serum lipid and lipoprotein profiles in type 2 diabetic patients. MATERIALS AND METHODS: In a randomized, double-blind, placebo controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months; group M: 200 mg Mg and 30 mg Zn (n = 16), group V: 200mg Vitamin C and 150 mg Vitamin E (n = 18), group MV: minerals plus vitamins (n = 17), group P: placebo (n = 18). Fasting blood and urine samples were collected at the beginning and at the end of the trial. Serum triglyceride, total cholesterol, high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) were measured enzymatically. Apolipoproteins (apo) A1 and B were measured by immunoturbidimetric method. Adjustment for differences in baselines covariates and changes in variables during study were performed by analysis of covariance using general linear models. RESULTS: Results indicate that after 3 months of supplementation mean serum levels of HDL-c and apo A1 increased significantly in the MV group by 24% (50.4 +/-19.3 mg/dl versus 40.6 +/- 10.8 mg/dl) and 8.8% (169.8 +/- 33.8 mg/dl versus 156.1+ /- 23.9 mg/dl), respectively (P < 0.01). There were no significant changes in the levels of these parameters in the other three groups. Serum levels of total cholesterol, LDL-c, triglyceride, and apo B were not altered after supplementation in all four groups. CONCLUSION: It is concluded that since co-supplementation of Mg, Zn, Vitamins C and E significantly increases HDL-c and apo A1, supplementation of these micronutrients could be recommended for the type 2 diabetic patients based on their daily requirements. |
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Authors:
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Maryam Sadat Farvid; Fereydoun Siassi; Mahmoud Jalali; Mostafa Hosseini; Navid Saadat |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 65 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-05-27 Completed Date: 2005-01-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 21-8 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. farvid@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apolipoprotein A-I / blood Apolipoproteins B / blood Ascorbic Acid / administration & dosage*, blood Cholesterol / blood Diabetes Mellitus, Type 2 / blood*, drug therapy* Dietary Supplements Double-Blind Method Eating Female Humans Interviews as Topic Lipids / blood* Magnesium / administration & dosage*, blood Male Middle Aged Triglycerides / blood Vitamin E / administration & dosage*, blood Zinc / administration & dosage*, blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Lipids; 0/Triglycerides; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 57-88-5/Cholesterol; 7439-95-4/Magnesium; 7440-66-6/Zinc |
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