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The impact of vitamin D on pregnancy: A systematic review.
MedLine Citation:
PMID:  22974137     Owner:  NLM     Status:  Publisher    
Hypovitaminosis D is common in pregnancy. To systematically review the evidence on vitamin D-dependent pregnancy outcomes, PubMed and Embase were searched for randomized control trials, cohort and case-control studies. In randomized control trials (n = 7), larger doses of vitamin D resulted in higher 25-hydroxylated vitamin D (25OHD) levels (n = 6); increased maternal weight gain (n = 1); and fewer classical vitamin D deficiency symptoms (n = 1). In observational studies (n = 32), lower vitamin D intake, or low 25OHD-levels, were associated with adverse fertility parameters (n = 2); preeclampsia (n = 5); gestational diabetes or higher blood glucose (n = 6); bacterial vaginosis (n = 4); primary cesarean section (n = 1); none (n = 3) or a few days' (n = 2) shorter gestation; and post partum depression (n = 1). Studies with few participants having low 25OHD did not identify an association to preeclampsia (n = 5) or gestational diabetes (n = 2). Increased odds of pregnancy-associated breast cancer with 25OHD >25.8 nmol/l were observed (n = 1). In conclusion, an effect of vitamin D on several pregnancy outcomes is suggested.
Henrik T Christesen; Tine Falkenberg; Ronald F Lamont; Jan S Jørgensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-14
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark Clinical Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark Department of Obstetrics and Gynaecology, Odense University Hospital, Odense, Denmark Division of Surgery, University College, London, UK.
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