Document Detail

The impact of therapeutic modality on outcomes following repair of ruptured intracranial aneurysms: an administrative data analysis. Clinical article.
MedLine Citation:
PMID:  19852537     Owner:  NLM     Status:  MEDLINE    
OBJECT: Enrolling a selected sample of ruptured intracranial aneurysms, the International Subarachnoid Aneurysm Trial (ISAT) found endovascular coiling to be superior to microsurgical clipping. The performance of coiling in a more general population of ruptured aneurysms has not been adequately studied. METHODS: Using provincial administrative data from Ontario, the authors conducted a retrospective cohort study of adult patients with subarachnoid hemorrhage (SAH) who underwent aneurysm repair. The exposure was defined as endovascular versus surgical aneurysm repair. The prespecified primary outcome was time to death or readmission for SAH. Data from the entire cohort were analyzed using a multivariable adjusted Cox proportional hazards model. Propensity scores were used to compare a matched subgroup of patients with aneurysms who had similar baseline characteristics. The potential impact of unmeasured confounding was assessed using sensitivity analysis. RESULTS: Between 1995 and 2004, 2342 aneurysms were clipped and 778 were coiled in Ontario. The proportion of aneurysms treated by coiling increased steadily over time. In the adjusted analysis of the entire cohort, endovascular coiling was associated with a significantly increased hazard of death or SAH readmission (hazard ratio 1.25 [95% CI 1.00–1.55], p = 0.04). Similar results were obtained from the propensity score matched analysis (hazard ratio 1.25 [95% CI 1.04–1.50], p = 0.02). Measures of procedural morbidity and mortality were not significantly different between groups. CONCLUSIONS: The results of the current analysis call into question the generalizability of the ISAT to all ruptured aneurysms. Given the limitations inherent in this form of analysis, further clinical studies—rigorously assessing the performance of endovascular therapy in patients with non-ISAT-like aneurysms—are indicated.
Cian J O'Kelly; Abhaya V Kulkarni; Peter C Austin; M Christopher Wallace; David Urbach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  113     ISSN:  1933-0693     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  795-801     Citation Subset:  AIM; IM    
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Aneurysm, Ruptured / mortality,  surgery*
Cohort Studies
Data Interpretation, Statistical
Databases, Factual
Follow-Up Studies
Intracranial Aneurysm / mortality,  surgery*
Kaplan-Meiers Estimate
Middle Aged
Neurosurgical Procedures / methods*
Proportional Hazards Models
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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