| The impact of testosterone administration to female-to-male transsexuals on insulin resistance and lipid parameters compared with women with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 20451188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the impact of testosterone (T) administration to female-to-male transsexuals (FtMs) on insulin resistance and lipid parameters and to compare the effects with women with polycystic ovary syndrome (PCOS). DESIGN: Cohort analysis. SETTING: University hospital. PATIENT(S): Twenty-nine FtMs and 240 women with PCOS. INTERVENTION(S): Screening panel, ultrasound of the ovaries, hormone, lipid, and glucose and insulin measurements. MAIN OUTCOME MEASURE(S): Endocrine, metabolic parameters, and insulin resistance. RESULT(S): The PCOS women had significantly higher fasting, 1-h, and 2-h insulin levels and a significantly lower insulin sensitivity index compared with FtMs before and after their T treatment. There were higher triglyceride levels and lower high-density lipoprotein cholesterol levels upon T treatment in FtMs compared with the PCOS women. Women with PCOS had higher body mass index (BMI) values. Positive correlations between insulin resistance indices and BMI were found only in women with PCOS. CONCLUSION(S): Testosterone administration by itself showed little detrimental influence on insulin resistance indices, but it had significant effects on lipid profiles. Compared with T, BMI had a greater impact on insulin resistance in women with PCOS. |
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Authors:
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Susanne Cupisti; Erik J Giltay; Louis J Gooren; Desiree Kronawitter; Patricia G Oppelt; Matthias W Beckmann; Ralf Dittrich; Andreas Mueller |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-05-07 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2647-53 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Female Hirsutism / blood, metabolism Humans Insulin Resistance* / physiology Lipid Metabolism / drug effects* Lipids / blood Male Polycystic Ovary Syndrome / blood, complications, metabolism* Testosterone / administration & dosage*, pharmacology Transsexualism / blood, drug therapy*, metabolism* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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