| The impact of taurine- and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effects. | |
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MedLine Citation:
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PMID: 20099004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Taurine, a substrate of taurine transporter, has functions as a neuromodulator and antioxidant and beta-alanine, a taurine transporter inhibitor, has a role as a neurotransmitter in the brain, and they were expected to be involved in depression-like behavior and antidepressant treatment. These facts aroused our interest in new capabilities of taurine and beta-alanine. Thus, to investigate the effects of chronic ingestion of taurine- (22.5 mmol/kg diet) supplemented diet and beta-alanine- (22.5 mmol/kg diet) supplemented diet under acute stressful conditions, behavioral changes and brain metabolites were compared with mice fed a control diet. In the open field test, no significant difference was observed in locomotor activity among groups. In the elevated plus-maze test, however, significant increases in the percentage of time spent and entries in the open arms were observed in the beta-alanine-supplemented diet fed group compared to both controls and animals fed with taurine-supplemented diet. Moreover, a significant decrease in the duration of immobility was observed in the taurine-supplemented diet group in the forced swimming test compared to both controls and animals fed with beta-alanine-supplemented diet. Taurine-supplemented diet increased taurine and L: -arginine concentrations in the hypothalamus. In contrast, beta-alanine-supplemented diet decreased the concentration of 5-hydroxyindoleacetic acid, a major metabolite of serotonin, in the hypothalamus. Beta-alanine-supplemented diet also increased carnosine (beta-alanyl-L: -histidine) concentration in the cerebral cortex and hypothalamus, and brain-derived neurotrophic factor concentration in the hippocampus. These results suggested that taurine-supplemented diet had an antidepressant-like effect and beta-alanine-supplemented diet had an anxiolytic-like effect. |
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Authors:
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Tatsuro Murakami; Mitsuhiro Furuse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-23 |
Journal Detail:
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Title: Amino acids Volume: 39 ISSN: 1438-2199 ISO Abbreviation: Amino Acids Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-25 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 427-34 Citation Subset: IM |
Affiliation:
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Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 812-8581, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Anxiety Agents / pharmacology* Antidepressive Agents / pharmacology* Arginine / metabolism Behavior, Animal / drug effects Brain-Derived Neurotrophic Factor / metabolism Carnosine / metabolism Cerebral Cortex / drug effects, metabolism Dietary Supplements Hippocampus / drug effects, metabolism Hydroxyindoleacetic Acid / metabolism Hypothalamus / drug effects, metabolism Male Mice Mice, Inbred ICR Stress, Psychological / drug therapy Taurine / metabolism, pharmacology* beta-Alanine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Brain-Derived Neurotrophic Factor; 107-35-7/Taurine; 107-95-9/beta-Alanine; 305-84-0/Carnosine; 54-16-0/Hydroxyindoleacetic Acid; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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