| The impact of storage effects in biobanks on biomarker discovery in systems biology studies. | |
| | |
MedLine Citation:
|
PMID: 20923317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sample handling and storage conditions in specimens frozen over long periods of time can severely impact marker levels. If laboratory technologies, practices and related protocols change over time, biomarker studies are potentially biased and report erroneous results. These issues and pitfalls are often overlooked in system biology studies using previously collected and stored materials, and are likely to be one notable cause for biomarker candidates failing to be validated. We present results from simulation studies quantifying the loss in statistical power to detect true biomarkers, due to diminishing concentration of analytes in samples subject to poor handling and storage conditions. |
| | |
Authors:
|
Raji Balasubramanian; Laurin Mueller; Karl Kugler; Werner Hackl; Lisa Pleyer; Matthias Dehmer; Armin Graber |
Related Documents
:
|
16512677 - Insilicospectro: an open-source proteomics library. 6645867 - Mechanical analysis of racket and ball during impact. 20407947 - A review of experimental design best practices for proteomics based biomarker discovery... 17990507 - Mining tandem mass spectral data to develop a more accurate mass error model for peptid... 12348067 - Endogenous fertility and the henry george theorem. 21527287 - Animal models of obsessive-compulsive disorder: exploring pharmacology and neural subst... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-10-05 |
Journal Detail:
|
Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: 15 ISSN: 1366-5804 ISO Abbreviation: Biomarkers Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-15 Completed Date: 2011-03-10 Revised Date: 2012-03-09 |
Medline Journal Info:
|
Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: England |
Other Details:
|
Languages: eng Pagination: 677-83 Citation Subset: IM |
Affiliation:
|
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers* Humans Models, Theoretical Specimen Handling / methods* Systems Biology* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Understanding physical factors associated with participation in community ambulation following strok...
Next Document: Evaluation of sit-to-stand motion using a pressure distribution measurement system - effect of diffe...