Document Detail


The impact of storage effects in biobanks on biomarker discovery in systems biology studies.
MedLine Citation:
PMID:  20923317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sample handling and storage conditions in specimens frozen over long periods of time can severely impact marker levels. If laboratory technologies, practices and related protocols change over time, biomarker studies are potentially biased and report erroneous results. These issues and pitfalls are often overlooked in system biology studies using previously collected and stored materials, and are likely to be one notable cause for biomarker candidates failing to be validated. We present results from simulation studies quantifying the loss in statistical power to detect true biomarkers, due to diminishing concentration of analytes in samples subject to poor handling and storage conditions.
Authors:
Raji Balasubramanian; Laurin Mueller; Karl Kugler; Werner Hackl; Lisa Pleyer; Matthias Dehmer; Armin Graber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2010-10-05
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  15     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-03-10     Revised Date:  2012-03-09    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  677-83     Citation Subset:  IM    
Affiliation:
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers*
Humans
Models, Theoretical
Specimen Handling / methods*
Systems Biology*
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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