Document Detail

The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B.
MedLine Citation:
PMID:  21033238     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Recently, several studies have indicated that liver stiffness measurement (LSM) using FibroScan accurately predicts liver fibrosis. This study investigated the impact of steatosis on LSM in patients with chronic hepatitis B (CHB).
METHODOLOGY: The study prospectively enrolled 162 patients (106 men and 56 women) with CHB who underwent both a liver biopsy and LSM between January 2005 and June 2008. We examined the overall univariate correlation between steatosis and LSM value and also performed a multivariate regression analysis to identify independent variables influencing LSM values.
RESULTS: The mean age of the patients was 44.4 years and the mean body mass index was 23.3 +/- 2.8kg/m2. The fibrosis stage ranged from F1 to F4 in 16 patients (9.9%), 37 (22.8%), 17 (10.5%) and 92 (56.8%), respectively. Steatosis was S0 in 128 patients (79.0%), S1 in 28 (17.3%), S2 in 6 (3.7%) and S3 in none. No overall significant correlation was noted between LSM value and steatosis (r = 0.023, p = 0.770). In the multivariate linear regression analysis, only fibrosis stage showed statistical significance (r = 0.268, p < 0.001), while steatosis did not (r = 0.013, p = 0.841).
CONCLUSIONS: Our findings suggest that mild to moderate steatosis does not have a significant impact on LSM values in patients with CHB.
Seung Up Kim; Do Young Kim; Sang Hoon Ahn; Hee Man Kim; Jung Min Lee; Chae Yoon Chon; Young Nyun Park; Kwang-Hyub Han; Jun Yong Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  57     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  832-8     Citation Subset:  IM    
Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Sodaemun-gu, Seoul 120-752, Republic of Korea.
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MeSH Terms
Fatty Liver / epidemiology,  pathology*
Hepatitis B, Chronic / epidemiology,  pathology*
Linear Models
Liver / pathology*
Middle Aged
Multivariate Analysis
Prospective Studies

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