Document Detail

The impact of rotary blood pump in conjunction with mechanical ventilation on ventricular energetic parameters - numerical simulation.
MedLine Citation:
PMID:  17019513     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Aim of this work is to study the impact of left ventricular rotary blood pump assistance, on energetic variables, when mechanical ventilation (MV) of the lungs is applied. METHODS: Computer simulation was used to perform this study. Lumped parameter models reproduce the circulatory system. Variable elastance models reproduce the Starling's law of the heart for each ventricle. After the reproduction of ischemic heart disease left ventricular assistance was applied using a model of rotary blood pump. The pump speed was changed in steps and was assumed to be constant during each step. The influence of mechanical ventilation was introduced by different values of positive mean thoracic pressure. RESULTS: The increase of the rotational speed has a significant influence on some ventricular energetic variables. In fact it decreased left ventricular external work, left and right ventricular pressure-volume area and the left ventricular efficiency. Finally, it increased the right ventricular efficiency but had no influence on the right ventricular external work. The increase of thoracic pressure from -2 to +5 mmHg caused a significant decrease of external work, pressure-volume area (right ventricular pressure-volume area dropped up to 50%) and an increase of right ventricular efficiency (by 40%) while left ventricular efficiency remained almost stable. CONCLUSIONS: Numerical simulation is a very suitable tool to predict changes of not easily measurable parameters such as energetic ventricular variables when mechanical assistance of heart and/or lungs is applied independently or simultaneously.
C De Lazzari; M Darowski; G Ferrari; D M Pisanelli; G Tosti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods of information in medicine     Volume:  45     ISSN:  0026-1270     ISO Abbreviation:  Methods Inf Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-04     Completed Date:  2006-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210453     Medline TA:  Methods Inf Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  574-83     Citation Subset:  IM    
C.N.R., Institute of Clinical Physiology - Rome Section, Cardiovascular Engineering Group, Italy.
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MeSH Terms
Computer Simulation
Heart-Assist Devices*
Respiration, Artificial*
Ventricular Function
Ventricular Pressure / physiology*

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