Document Detail

The impact of rosiglitazone on cardiovascular responses and endurance during isometric exercise in patients with Type 2 diabetes.
MedLine Citation:
PMID:  16369466     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vascular endothelial function is compromised in people with diabetes reducing tissue blood flow. The present investigation was a logical extension of a previous work, examining isometric exercise performance and recovery in people with diabetes and the impact of the insulin sensitizer rosiglitazone, a drug shown to improve endothelial function. MATERIAL/METHODS: Blood pressure, heart rate and limb blood flow were examined in 12 control subjects and 8 subjects with type 2 diabetes during a series of 2 fatiguing isometric contractions at a tension of 40% of the maximum strength of the handgrip muscles; 5 minutes of rest were allowed between the contractions. RESULTS: Endurance of the first and the second contraction was significantly less in subjects with diabetes (p<0.01). HR increased significantly (p<0.01) by over three fold during exercise in control subjects compared to subjects with diabetes. There was no statistical difference in the increase in either systolic or diastolic BP during isometric exercise comparing controls to subjects with Type 2 diabetes (p>0.05), however, resting and peak blood pressures were greater in subjects with type 2 diabetes (p<0.01). Forearm blood flow, which was significantly lower at rest (p<0.01) in subjects with diabetes, only increased by about half as much during the exercise in subjects compared to control subjects. These differences were partially reversed after 3 months administration of rosiglitazone. CONCLUSIONS: Microcirculatory damage in diabetes impairs exercise performance and recovery and can be partially reversed after rosiglitazone administration.
Jerrold Scott Petrofsky; Scott Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-19
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  12     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR21-26     Citation Subset:  IM    
Department of Physical Therapy and Endocrinology, Loma Linda University, Loma Linda, CA 92350, U.S.A.
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Diabetes Mellitus, Type 2*
Forearm / blood supply
Heart Rate / drug effects
Hypoglycemic Agents / pharmacology*
Isometric Contraction / physiology*
Physical Endurance* / drug effects,  physiology
Regional Blood Flow / drug effects
Thiazolidinediones / pharmacology*
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Thiazolidinediones; 0/Vasodilator Agents; 122320-73-4/rosiglitazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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