Document Detail


The impact of a regular erythrocytapheresis programme on the acute and chronic complications of sickle cell disease in adults.
MedLine Citation:
PMID:  20346014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirteen adult patients aged 22-63 (median 30) years with sickle cell disease (SCD) were enrolled in a regular erythrocytapheresis (ECP) programme at a single institution between December 1998 and November 2008. The indications for enrolment were recurrent painful crises (PC), acute chest syndrome (ACS), silent cortical ischaemia, pulmonary hypertension, multi-organ crises and pregnancy. Endpoints retrospectively evaluated included the incidence of SCD-related acute events requiring hospitalization following and prior to regular ECP, the development of new and progression of pre-existing related end-organ damage, the effectiveness in reducing HbS levels acutely and prior to the next exchange and the transfusion-related complications. Sixteen acute sickle-related events occurred in five patients in 846 months of patient follow-up. In all patients with reliable data available pre-ECP, the frequency of such events was reduced following commencing regular ECP. No patient experienced stroke, multi-organ crises or developed new and/or progression of end-organ dysfunction. Regular ECP reduced HbS levels to the target of <30% immediately post-exchange. Alloimmunization rates were comparable to the literature and ECP was effective in preventing progressive iron overload. Regular ECP was demonstrated to be an effective, well-tolerated therapy for both acute and chronic complications of SCD in adults.
Authors:
Anna Kalff; Claire Dowsing; Andrew Grigg
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-03-21
Journal Detail:
Title:  British journal of haematology     Volume:  149     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-07-29     Revised Date:  2011-09-23    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  768-74     Citation Subset:  IM    
Affiliation:
Department of Laboratory Haematology, Royal Melbourne Hospital, Vic., Australia. akalff@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Anemia, Sickle Cell / complications,  economics,  therapy*
Chronic Disease
Cytapheresis / economics,  methods*
Erythrocyte Transfusion / adverse effects,  economics,  methods*
Female
Health Care Costs / statistics & numerical data
Hospitalization
Humans
Male
Middle Aged
Multiple Organ Failure / etiology,  prevention & control
Retrospective Studies
Young Adult
Comments/Corrections
Comment In:
Br J Haematol. 2011 Sep;154(5):656-9   [PMID:  21517812 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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