| The impact of a regular erythrocytapheresis programme on the acute and chronic complications of sickle cell disease in adults. | |
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MedLine Citation:
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PMID: 20346014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirteen adult patients aged 22-63 (median 30) years with sickle cell disease (SCD) were enrolled in a regular erythrocytapheresis (ECP) programme at a single institution between December 1998 and November 2008. The indications for enrolment were recurrent painful crises (PC), acute chest syndrome (ACS), silent cortical ischaemia, pulmonary hypertension, multi-organ crises and pregnancy. Endpoints retrospectively evaluated included the incidence of SCD-related acute events requiring hospitalization following and prior to regular ECP, the development of new and progression of pre-existing related end-organ damage, the effectiveness in reducing HbS levels acutely and prior to the next exchange and the transfusion-related complications. Sixteen acute sickle-related events occurred in five patients in 846 months of patient follow-up. In all patients with reliable data available pre-ECP, the frequency of such events was reduced following commencing regular ECP. No patient experienced stroke, multi-organ crises or developed new and/or progression of end-organ dysfunction. Regular ECP reduced HbS levels to the target of <30% immediately post-exchange. Alloimmunization rates were comparable to the literature and ECP was effective in preventing progressive iron overload. Regular ECP was demonstrated to be an effective, well-tolerated therapy for both acute and chronic complications of SCD in adults. |
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Authors:
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Anna Kalff; Claire Dowsing; Andrew Grigg |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2010-03-21 |
Journal Detail:
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Title: British journal of haematology Volume: 149 ISSN: 1365-2141 ISO Abbreviation: Br. J. Haematol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-07-29 Revised Date: 2011-09-23 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 768-74 Citation Subset: IM |
Affiliation:
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Department of Laboratory Haematology, Royal Melbourne Hospital, Vic., Australia. akalff@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Anemia, Sickle Cell / complications, economics, therapy* Chronic Disease Cytapheresis / economics, methods* Erythrocyte Transfusion / adverse effects, economics, methods* Female Health Care Costs / statistics & numerical data Hospitalization Humans Male Middle Aged Multiple Organ Failure / etiology, prevention & control Retrospective Studies Young Adult |
| Comments/Corrections | |
Comment In:
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Br J Haematol. 2011 Sep;154(5):656-9
[PMID:
21517812
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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