| The impact of reflux composition on mucosal injury and esophageal function. | |
| | |
MedLine Citation:
|
PMID: 16769534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The components of refluxed gastric juice are known to cause mucosal injury, but their effect on esophageal function is less appreciated. Our aim was to determine the effect of acid and/or bile on mucosal injury and esophageal function. From 1993-2004, 402 patients with reflux symptoms had 24-hour pH and Bilitec monitoring, manometry, and endoscopy with biopsies. Mucosal injury (esophagitis or Barrett's esophagus) and esophageal function (lower esophageal sphincter [LES] characteristics and body contractility) in patients with acid reflux, bile reflux, or both were compared with patients without reflux. Reflux was present in 273/402 patients; of these, 37 (13.5%) had increased exposure to bile, 82 (30.0%) had increased exposure to acid, and 154 (56.4%) had increased exposure to both. Mucosal injury was most common with increased mixed acid and bile exposure, followed by acid alone, and was uncommon with bile alone (P < 0.0001). Functional deterioration paralleled mucosal injury (P < 0.0001). Mixed acid and bile exposure was present in more than half of patients with reflux and was associated with the most severe mucosal injury and the greatest deterioration of esophageal function. This suggests that composition of gastric juice is the primary determinant of inflammatory mucosal injury and subsequent loss of esophageal function. |
| | |
Authors:
|
Daniel S Oh; Jeffrey A Hagen; Martin Fein; Cedric G Bremner; Christy M Dunst; Steven R Demeester; John Lipham; Tom R Demeester |
Related Documents
:
|
19063984 - Cough and gastroesophageal reflux: from the gastroenterologist end. 1855354 - Tolerance to nicotinic acid flushing. 9854904 - Synthesis of nad+ in erythrocytes incubated with nicotinic acid and the effect of di-(2... 16257484 - The promoter of the human sodium/iodide symporter responds to certain phthalate plastic... 8429464 - Early hepatobiliary dysfunction during total parenteral nutrition: an experimental study. 6627524 - A new synthesis of bis(diacylglycero)phosphate. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Volume: 10 ISSN: 1091-255X ISO Abbreviation: J. Gastrointest. Surg. Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-06-13 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9706084 Medline TA: J Gastrointest Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 787-96; discussion 796-7 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Endoscopy, Gastrointestinal Esophageal Diseases / etiology Esophagus / physiopathology* Female Gastric Juice / chemistry* Gastroesophageal Reflux / complications, physiopathology, surgery* Humans Hydrogen-Ion Concentration Male Manometry Middle Aged Monitoring, Ambulatory Mucous Membrane / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ASPAN and the organizational EBP vision: synergistic opportunities for perianesthesia nurses.
Next Document: Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left...