Document Detail

The impact of raised BMI on the outcome of assisted reproduction: Current concepts.
MedLine Citation:
PMID:  21973124     Owner:  NLM     Status:  In-Data-Review    
Obesity contributes to worse outcomes following treatment using assisted reproductive technology (ART), including lower pregnancy and live birth rates and a higher miscarriage rate. This could be mediated through a detrimental effect on oocyte and embryo quality. Oocyte donation studies have suggested that endometrial changes also play a significant role. Endocrine changes associated with obesity, including hyperandrogenism and insulin resistance, as well as changes in local levels of IGFs, cytokines and leptin are thought to underlie the relationship between raised BMI and adverse ART outcomes. This review aims to highlight these underlying mechanisms.
S Sobaleva; T El-Toukhy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  31     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  561-5     Citation Subset:  IM    
Guy's and St Thomas' Hospital NHS Foundation Trust , London , UK.
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