| The impact of raised BMI on the outcome of assisted reproduction: Current concepts. | |
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MedLine Citation:
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PMID: 21973124 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Obesity contributes to worse outcomes following treatment using assisted reproductive technology (ART), including lower pregnancy and live birth rates and a higher miscarriage rate. This could be mediated through a detrimental effect on oocyte and embryo quality. Oocyte donation studies have suggested that endometrial changes also play a significant role. Endocrine changes associated with obesity, including hyperandrogenism and insulin resistance, as well as changes in local levels of IGFs, cytokines and leptin are thought to underlie the relationship between raised BMI and adverse ART outcomes. This review aims to highlight these underlying mechanisms. |
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Authors:
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S Sobaleva; T El-Toukhy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Volume: 31 ISSN: 1364-6893 ISO Abbreviation: J Obstet Gynaecol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309140 Medline TA: J Obstet Gynaecol Country: England |
Other Details:
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Languages: eng Pagination: 561-5 Citation Subset: IM |
Affiliation:
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Guy's and St Thomas' Hospital NHS Foundation Trust , London , UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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