| The impact of prostanoids on pulmonary gas exchange during abdominal surgery with mesenteric traction. | |
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MedLine Citation:
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PMID: 9249099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effect of intravenous (iv) ibuprofen on prostanoid release and on pulmonary gas exchange after abdominal mesenteric traction (MT) during either abdominal aortic surgery or pancreas resection. In a prospective, randomized, double-blind study, 400 mg ibuprofen (pancreas n = 13, aorta n = 13) or a placebo (pancreas n = 13, aorta n = 13) was administered iv before skin incision. MT was applied uniformly. The prostanoid plasma concentrations, venous admixture (Q(va)/Q(t)), and PaO2/FIO2 ratio were determined at baseline (before MT) and 5, 15, 45, and 90 min after MT. Patients who underwent aortic surgery were older and exhibited a lower preoperative PaO2 than those who underwent pancreas resection. Placebo-treated patients revealed a 30-fold peak increase in 6-keto-prostaglandin F1alpha (stable metabolite of prostacyclin) levels after intentional MT during aortic as well as pancreatic operations. This response was accompanied by an increase in Q(va)/Q(t) (ibuprofen: pancreas 7% +/- 1%, aorta 14% +/- 2%; placebo: pancreas 16% +/- 3%, aorta 26% +/- 3%/15 min after MT [mean +/- SEM, P < 0.05, placebo vs ibuprofen]), which resulted in decreased PaO2/ FIO2 ratio only in the aortic surgery patients (ibuprofen: 310 +/- 19; placebo: 237 +/- 24 15 min after MT, [mean +/- SEM, P < 0.05]). The authors conclude that ibuprofen-pretreated patients demonstrated almost constant prostanoid levels without changes in pulmonary gas exchange after MT. |
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Authors:
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A Brinkmann; W Seeling; C F Wolf; E Kneitinger; F Vogeser; M Rockemann; U Brückner; P Radermacher; M Büchler; M Georgieff |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 85 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 274-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, University Clinics Ulm (Donau), Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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blood,
secretion Aged Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacology, therapeutic use* Aorta, Abdominal / surgery* Cyclooxygenase Inhibitors / administration & dosage, pharmacology, therapeutic use* Dinoprostone / blood, secretion Double-Blind Method Epoprostenol / blood, secretion Female Humans Ibuprofen / administration & dosage, pharmacology, therapeutic use* Injections, Intravenous Intraoperative Care* Male Mesentery / pathology* Middle Aged Oxygen / blood Pancreatectomy* Placebos Prospective Studies Prostaglandins / blood, secretion* Pulmonary Gas Exchange / drug effects* Pulmonary Veins Thromboxane B2 / blood, secretion Traction |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 0/Placebos; 0/Prostaglandins; 15687-27-1/Ibuprofen; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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