|The impact of prostanoids on pulmonary gas exchange during abdominal surgery with mesenteric traction.|
|PMID: 9249099 Owner: NLM Status: MEDLINE|
|We investigated the effect of intravenous (iv) ibuprofen on prostanoid release and on pulmonary gas exchange after abdominal mesenteric traction (MT) during either abdominal aortic surgery or pancreas resection. In a prospective, randomized, double-blind study, 400 mg ibuprofen (pancreas n = 13, aorta n = 13) or a placebo (pancreas n = 13, aorta n = 13) was administered iv before skin incision. MT was applied uniformly. The prostanoid plasma concentrations, venous admixture (Q(va)/Q(t)), and PaO2/FIO2 ratio were determined at baseline (before MT) and 5, 15, 45, and 90 min after MT. Patients who underwent aortic surgery were older and exhibited a lower preoperative PaO2 than those who underwent pancreas resection. Placebo-treated patients revealed a 30-fold peak increase in 6-keto-prostaglandin F1alpha (stable metabolite of prostacyclin) levels after intentional MT during aortic as well as pancreatic operations. This response was accompanied by an increase in Q(va)/Q(t) (ibuprofen: pancreas 7% +/- 1%, aorta 14% +/- 2%; placebo: pancreas 16% +/- 3%, aorta 26% +/- 3%/15 min after MT [mean +/- SEM, P < 0.05, placebo vs ibuprofen]), which resulted in decreased PaO2/ FIO2 ratio only in the aortic surgery patients (ibuprofen: 310 +/- 19; placebo: 237 +/- 24 15 min after MT, [mean +/- SEM, P < 0.05]). The authors conclude that ibuprofen-pretreated patients demonstrated almost constant prostanoid levels without changes in pulmonary gas exchange after MT.|
|A Brinkmann; W Seeling; C F Wolf; E Kneitinger; F Vogeser; M Rockemann; U Brückner; P Radermacher; M Büchler; M Georgieff|
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|Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't|
|Title: Anesthesia and analgesia Volume: 85 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1997 Aug|
|Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES|
|Languages: eng Pagination: 274-80 Citation Subset: AIM; IM|
|Department of Anesthesiology, University Clinics Ulm (Donau), Germany.|
|APA/MLA Format Download EndNote Download BibTex|
6-Ketoprostaglandin F1 alpha
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacology, therapeutic use*
Aorta, Abdominal / surgery*
Cyclooxygenase Inhibitors / administration & dosage, pharmacology, therapeutic use*
Dinoprostone / blood, secretion
Epoprostenol / blood, secretion
Ibuprofen / administration & dosage, pharmacology, therapeutic use*
Mesentery / pathology*
Oxygen / blood
Prostaglandins / blood, secretion*
Pulmonary Gas Exchange / drug effects*
Thromboxane B2 / blood, secretion
|0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 0/Placebos; 0/Prostaglandins; 15687-27-1/Ibuprofen; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 7782-44-7/Oxygen|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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