Document Detail

The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injury.
MedLine Citation:
PMID:  17522989     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury (TBI) who either received or did not receive anti-epileptic prophylactic treatment.
METHODS: Two populations were studied: 55 patients retrospectively and 82 subjects prospectively.
RESULTS: Ten patients (18%) in the first population showed late PTE. Although the incidence was lower in patients who did not receive prophylactic treatment, the difference between the treated and the non-treated group was not statistically significant. Sixty-nine patients in the second group (84%) had prophylactic treatment. Twenty-seven patients (39%) suffered from late PTE during the 2-year follow-up period and 17 of them (63%) showed EEG epileptic abnormalities. No patient who did not receive preventive therapy suffered from late PTE during the observation period.
CONCLUSIONS: Due to the negative cognitive effects of anti-epileptic drugs, the preliminary results are of considerable interest for the rehabilitation of patients with very severe TBI.
R Formisano; C Barba; M G Buzzi; J Newcomb-Fernandez; F Menniti-Ippolito; R Zafonte; V Vinicola; F Spanedda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain injury     Volume:  21     ISSN:  0269-9052     ISO Abbreviation:  Brain Inj     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-24     Completed Date:  2008-02-05     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  England    
Other Details:
Languages:  eng     Pagination:  499-504     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / administration & dosage,  therapeutic use*
Brain Injuries / complications*,  drug therapy*,  rehabilitation
Cohort Studies
Drug Administration Schedule
Epilepsy / diagnosis,  epidemiology*,  prevention & control*
Middle Aged
Retrospective Studies
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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