| The impact of previous or concomitant IFN therapy on deferiprone-induced agranulocytosis and neutropenia: a retrospective study. | |
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MedLine Citation:
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PMID: 20945995 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Although IFN therapy is known to cause neutropenia, data on the risk of deferiprone (DFP)-induced haematological complications in patients receiving IFN are lacking. RESEARCH DESIGN AND METHODS: This was a retrospective single-centre study to assess the association between exposure to IFN for hepatitis C virus treatment and haematological side effects of DFP therapy in patients with thalassemia major and intermedia using a large database spanning 2001 – 2008. During observation time, a total of 66 patients, including 63 affected by thalassemia major and 3 by thalassemia intermedia, were treated with chelation DFP-based regimens. A subset of 25 patients was treated at least for 3 months also with IFN (6 were cotreated and 19 were pretreated). RESULTS: Overall, the incidence of neutropenia and agranulocytosis was 9.83 and 1.14/100 patient/year, respectively. Receipt of IFN was significantly associated with increased risk of haematological complications of DFP therapy: among patients receiving IFN, 48 and 12% experienced at least one episode of neutropenia and agranulocytosis, respectively. CONCLUSIONS: These results suggest that IFN therapy may increase the risk of complications of DFP-based iron chelation therapy in patients with thalassemia. Further research is needed to assess whether the association observed in this retrospective single-centre observational study is due to IFN or other factors. |
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Authors:
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Paolo Ricchi; Massimiliano Ammirabile; Silvia Costantini; Patrizia Cinque; Alfonso Galeota Lanza; Anna Spasiano; Tiziana Di Matola; Giovanni Di Costanzo; Leonilde Pagano; Luciano Prossomariti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on drug safety Volume: 9 ISSN: 1744-764X ISO Abbreviation: Expert Opin Drug Saf Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101163027 Medline TA: Expert Opin Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 875-81 Citation Subset: IM |
Affiliation:
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Dipartimento di oncoematologia, U.O.C. Centro delle Microcitemie A. Mastrobuoni, Azienda Ospedaliera di Rilievo Nazionale A. Cardarelli, Via A. Cardarelli 9, Naples, Italy. pabloricchi@libero.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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