Document Detail


The impact of prenatal stress, fetal alcohol exposure, or both on development: perspectives from a primate model.
MedLine Citation:
PMID:  11750784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The question of whether psychosocial stress during pregnancy (alone or in combination with fetal alcohol exposure) has negative consequences for offspring has not been clearly established in human studies. In this article, we present an overview of three prospective longitudinal studies. Using rhesus monkeys as subjects, a noise or hormone stressor, alone or in combination with moderate level alcohol solution, was presented daily during different stages of pregnancy. Prenatal stress resulted in lighter birth weights in two of three studies, and males from the alcohol plus noise stress condition had reduced birth weights. There were no significant effects of any of the prenatal treatments on gestation duration. Both prenatal stress and moderate fetal alcohol exposure reduced attention span and neuromotor capabilities of offspring during the first month of life, while early gestation prenatal stress, during the period of neuronal migration, emerged as a period of enhanced vulnerability for these effects. Under conditions of challenge, prenatally stressed monkeys showed more disturbance behaviors and reduced locomotion and exploration as well as altered hypothalamic-pituitary-adrenal (HPA) axis reactivity to stress. Fetal alcohol exposed monkeys also showed increased HPA axis activity in response to stressful conditions. Finally, altered patterns of alcohol consumption during adolescence were associated with prenatal stress.
Authors:
Mary L Schneider; Colleen F Moore; Gary W Kraemer; Andrew D Roberts; Onofre T DeJesus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  27     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-03-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-98     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, 2175 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA. schneider@education.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / psychology
Animals
Animals, Newborn
Behavior / drug effects
Behavior, Animal / drug effects
Birth Weight
Brain / radionuclide imaging
Central Nervous System Depressants / toxicity*
Ethanol / toxicity*
Female
Fetal Alcohol Syndrome / psychology*
Learning / drug effects
Macaca mulatta
Male
Pregnancy
Prenatal Exposure Delayed Effects*
Stress, Psychological / pathology,  psychology*,  radionuclide imaging
Tomography, Emission-Computed
Grant Support
ID/Acronym/Agency:
AA10079/AA/NIAAA NIH HHS; MCJ009102//PHS HHS; MH48417/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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