| The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients. | |
| | |
MedLine Citation:
|
PMID: 22234163 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Hyperglycemia, hypoglycemia and increased glycemic variability are independently associated with increased risk of mortality in critically ill patients. The purpose of this review is to evaluate the evidence from interventional trials of intensive insulin therapy, as well as observational cohort studies, relating premorbid diabetic status and these three domains of glycemic control to mortality. RECENT FINDINGS: Hyperglycemia has a stronger association with mortality in critically ill patients without diabetes than in those with diabetes. Hypoglycemia is independently associated with increased risk of mortality in both populations. Limited data suggest that increased glycemic variability may have a stronger association with mortality in patients without diabetes than in those with diabetes. SUMMARY: Premorbid diabetic status impacts the relationship of the three domains of glycemic control to risk of mortality in critically ill patients. The data presented in this review are hypothesis generating; future trials of IIT in the critically ill should stratify management and outcomes by premorbid diabetic status. |
| | |
Authors:
|
James S Krinsley; Geert Meyfroidt; Greet van den Berghe; Mori Egi; Rinaldo Bellomo |
Related Documents
:
|
21251603 - Factors associated with glycemic control and diabetes self-care among outpatients with ... 12713453 - Increased intestinal permeability as a cause of fluctuating postprandial blood glucose ... 18633113 - Plasma fetuin-a levels and the risk of type 2 diabetes. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
|
Title: Current opinion in clinical nutrition and metabolic care Volume: - ISSN: 1473-6519 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
aDivision of Critical Care, Stamford Hospital, Columbia University College of Physicians and Surgeons, Stamford, Connecticut, USA bDepartment of Intensive Care Medicine, University of Leuven (K.U. Leuven), Leuven, Belgium cDepartment of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan dDepartment of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Signaling the induction of sporulation involves the interaction of two secondary metabolites in Aspe...
Next Document: Alternatives to prokinetics to move the pylorus and colon.