Document Detail


The impact of pregnancy and childbirth on the metabolism of lamotrigine.
MedLine Citation:
PMID:  14745072     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters. LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline.
Authors:
P B Pennell; D J Newport; Z N Stowe; S L Helmers; J Q Montgomery; T R Henry
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  62     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2005-01-14     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  AIM; IM    
Affiliation:
Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. page_pennell@emoryhealthcare.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticonvulsants / administration & dosage,  blood,  pharmacokinetics*
Epilepsy / drug therapy,  metabolism*
Female
Humans
Metabolic Clearance Rate
Pregnancy
Pregnancy Complications / drug therapy,  metabolism*
Pregnancy Trimesters / blood
Puerperal Disorders / drug therapy,  metabolism*
Triazines / administration & dosage,  blood,  pharmacokinetics*
Grant Support
ID/Acronym/Agency:
1P50 MH68036-01/MH/NIMH NIH HHS; K23 MH63507-03/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; U3H27498KS/lamotrigine
Comments/Corrections
Erratum In:
Neurology. 2010 Jun 15;74(24):2028

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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