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The impact of pregnancy on the HIV-1-specific T cell function in infected pregnant women.
MedLine Citation:
PMID:  23103487     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Evidences indicate that pregnancy can alter the Ag-specific T-cell responses. This work aims to evaluate the impact of pregnancy on the in vitro HIV-1-specific immune response. As compared with non-pregnant patients, lower T-cell proliferation and higher IL-10 production were observed in T-cell cultures from pregnant patients following addition of either mitogens or HIV-1 antigens. In our system, the main T lymphocyte subset involved in producing IL-10 was CD4(+)FoxP3(-). Depletion of CD4(+) cells elevated TNF-α and IFN-γ production. Interestingly, the in vitro HIV-1 replication was lower in cell cultures from pregnant patients, and it was inversely related to IL-10 production. In these cultures, the neutralization of IL-10 by anti-IL-10 mAb elevated TNF-α release and HIV-1 replication. In conclusion, our results reveal that pregnancy-related events should favor the expansion of HIV-1-specific IL-10-secreting CD4(+) T-cells in HIV-1-infected women, which should, in the scenario of pregnancy, help to reduce the risk of vertical HIV-1 transmission.
Authors:
Joana Hygino; Morgana M Vieira; Taissa M Kasahara; Luciana F Xavier; Bernardo Blanco; Landi V C Guillermo; Renato G S Filho; Carmen S M Saramago; Agostinho A Lima-Silva; Ariane L Oliveira; Vander Guimarães; Arnaldo F B Andrade; Cleonice A M Bento
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  145     ISSN:  1521-7035     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  177-188     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Microbiology and Parasitology, Federal University of State of Rio de Janeiro, Rio de Janeiro, Brazil.
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