Document Detail


The impact of polyamine analogues on the blood pressure of normotensive and hypertensive rats.
MedLine Citation:
PMID:  8563697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The impact of the antineoplastic polyamine analogues N1N14-diethylhomospermine (DEHSPM) and N1N11-diethylnorspermine (DENSPM) on the blood pressure and heart rate of normotensive and hypertensive rats are described. DEHSPM was administered to both normotensive and spontaneously hypertensive rats (SHR), while the DENSPM analogue was given only to the normotensive animals. The intravenous administration of DEHSPM at doses of 5 or 10 mg/kg resulted in a profound and long-lasting drop in the test animals' blood pressure, with no appreciable change in their heart rate. This was true for both the normotensive and the hypertensive animals. When administered at equivalent molar dosages, DENSPM was one fifth as effective as DEHSPM at reducing blood pressure. The impact of NG-nitro-L-arginine-methyl ester (L-NAME) and L-arginine on the analogues' activity is consistent with the involvement of nitric oxide.
Authors:
R J Bergeron; J Wiegand; C A Sninsky; M J Katovich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  17     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-03-07     Completed Date:  1996-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1197-217     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, University of Flordia J. Hillis Miller Health Center Gainesville 32610, USA.
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MeSH Terms
Descriptor/Qualifier:
Amines / metabolism
Animals
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hypertension / metabolism,  physiopathology*
Male
Rats
Rats, Inbred SHR
Rats, Wistar
Spermine / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Amines; 119422-08-1/N(1),N(14)-bis(ethyl)homospermine; 121749-39-1/N(1),N(11)-diethylnorspermine; 71-44-3/Spermine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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