Document Detail


The impact of placental malaria on gestational age and birth weight.
MedLine Citation:
PMID:  10823776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal malaria is associated with reduced birth weight, which is thought to be effected through placental insufficiency, which leads to intrauterine growth retardation (IUGR). The impact of malaria on preterm delivery is unclear. The effects of placental malaria-related changes on birth weight and gestational age were studied in 1177 mothers (and their newborns) from Tanzania. Evidence of malaria infection was found in 75.5% of placental samples. Only massive mononuclear intervillous inflammatory infiltration (MMI) was associated with increased risk of low birth weight (odds ratio ¿OR, 4.0). Maternal parasitized red blood cells and perivillous fibrin deposition both were associated independently with increased risk of premature delivery (OR, 3.2; OR, 2.1, respectively). MMI is an important mechanism in the pathogenesis of IUGR in malaria-infected placentas. This study also shows that placental malaria causes prematurity even in high-transmission areas. The impact of maternal malaria on infant mortality may be greater than was thought previously.
Authors:
C Menendez; J Ordi; M R Ismail; P J Ventura; J J Aponte; E Kahigwa; F Font; P L Alonso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2000-05-15
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  181     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-20     Completed Date:  2000-07-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1740-5     Citation Subset:  AIM; IM    
Affiliation:
Unidad de Epidemiologia y Bioestadistica, Hospital Clinic, E-08036, Barcelona, Spain. menendez@clinic.ub.es.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight*
Chorionic Villi Sampling
Female
Fetal Growth Retardation / parasitology
Fibrin / analysis
Gestational Age*
Humans
Infant, Low Birth Weight
Infant, Newborn
Infectious Disease Transmission, Vertical*
Malaria, Falciparum / transmission*
Odds Ratio
Placenta / parasitology,  pathology
Pregnancy
Pregnancy Complications, Parasitic*
Tanzania
Chemical
Reg. No./Substance:
9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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