| The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer. | |
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MedLine Citation:
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PMID: 21813729 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ovarian cancer is the most lethal gynecological malignancy affecting American women. Current hypotheses concerning the etiology of ovarian cancer propose that a reduction in the lifetime number of ovulations decreases ovarian cancer risk. Advanced serous carcinoma shares several biomarkers with fallopian tube epithelial cells, suggesting that some forms of ovarian carcinoma may originate in the fallopian tube. Currently, the impact of ovulation on the tubal epithelium is unknown. In CD1 mice, ovulation did not increase tubal epithelial cell proliferation as measured by bromodeoxyuridine incorporation and proliferating cell nuclear antigen staining as compared to unstimulated animals. In superovulated mice, an increase in the number of pro-inflammatory macrophages was detected in the oviduct. Ovulation also increased levels of phospho-γH2A.X in tubal epithelial cells, indicating that these cells were susceptible to double-strand DNA breakage following ovulation. To determine which components of ovulation contributed to DNA damage in the fallopian tube, an immortalized baboon tubal epithelial cell line and a three-dimensional organ culture system for mouse oviduct and baboon fallopian tubes were developed. Tubal epithelial cells did not proliferate or display increased DNA damage in response to the gonadotropins or estradiol alone in vitro. Oxidative stress generated by treatment with hydrogen peroxide or macrophage-conditioned medium increased DNA damage in tubal epithelial cells in culture. Ovulation may impact the fallopian tube epithelium by generating DNA damage and stimulating macrophage infiltration, but does not increase proliferation through gonadotropin signaling. |
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Authors:
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Shelby Marie King; Tyvette S Hilliard; Lucia Y Wu; Randal Jaffe; Asgerally T Fazleabas; Joanna Elizabeth Burdette |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-3 |
Journal Detail:
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Title: Endocrine-related cancer Volume: - ISSN: 1479-6821 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436481 Medline TA: Endocr Relat Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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S King, Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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