Document Detail

The impact of ovarian stimulation for IVF on the developing embryo.
MedLine Citation:
PMID:  19710204     Owner:  NLM     Status:  MEDLINE    
The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1-3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes. In this review, we consider the evidence for these effects and address possible underlying mechanisms. We conclude that such mechanisms are still poorly understood, and further knowledge is needed in order to increase the safety of ovarian stimulation and to reduce potential effects on embryo development and implantation, which will ultimately be translated into increased pregnancy rates and healthy offspring.
Margarida Avo Santos; Ewart W Kuijk; Nick S Macklon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  139     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-34     Citation Subset:  IM    
University Medical Centre Utrecht, Reproductive Medicine and Gynaecology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
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MeSH Terms
Embryo Implantation / drug effects
Embryo, Mammalian / drug effects*
Embryonic Development / drug effects*
Epigenesis, Genetic / drug effects
Fertilization in Vitro* / methods,  statistics & numerical data,  trends
Follicle Stimulating Hormone / adverse effects*,  pharmacology,  therapeutic use
Infertility / therapy
Oocytes / drug effects
Ovulation Induction / adverse effects*,  methods
Pregnancy Outcome
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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