Document Detail

The impact of organic inhibitors of the hyperpolarization activated current (Ih) on the electroretinogram (ERG) of rodents.
MedLine Citation:
PMID:  15248565     Owner:  NLM     Status:  MEDLINE    
We have compared the effect of two distinct Ih inhibitors on the temporal properties of the ERG response that, as previously shown, correlates well with the HCN activation in rods. The present results confirm the notion that cilobradine is more effective than zatebradine in inducing bradycardia. Importantly, the doses of cilobradine that reduce the heart rate to values comparable to, or lower than, those obtained with higher doses of zatebradine have little effect on the frequency response of the ERG. While more potent than zatebradine in its bradycardic action, cilobradine appears comparatively less effective on the visual response. A possible explanation is that the affinity of cilobradine for the HCN channels in the heart is higher than that for the HCN channels of retinal neurons.
R Maccarone; G Izzizzari; C Gargini; L Cervetto; S Bisti
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives italiennes de biologie     Volume:  142     ISSN:  0003-9829     ISO Abbreviation:  Arch Ital Biol     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-07-13     Completed Date:  2004-09-23     Revised Date:  2009-10-05    
Medline Journal Info:
Nlm Unique ID:  0372441     Medline TA:  Arch Ital Biol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  95-103     Citation Subset:  IM    
Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, Italy.
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MeSH Terms
Benzazepines / pharmacology*
Bradycardia / chemically induced
Cardiotonic Agents / pharmacology
Dose-Response Relationship, Drug
Electroretinography / drug effects
Heart / drug effects*,  physiology
Heart Rate / drug effects,  physiology
Ion Channels / drug effects*,  physiology
Membrane Potentials / drug effects,  physiology
Piperidines / pharmacology
Rats, Long-Evans
Retina / drug effects*,  physiology
Retinal Ganglion Cells / drug effects,  physiology
Retinal Rod Photoreceptor Cells / drug effects,  physiology
Tachycardia / drug therapy
Reg. No./Substance:
0/Benzazepines; 0/Cardiotonic Agents; 0/Ion Channels; 0/Piperidines; 0/cilobradine; 85175-67-3/zatebradine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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