| The impact of obesity on oocytes: evidence for lipotoxicity mechanisms. | |
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MedLine Citation:
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PMID: 22394715 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality. |
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Authors:
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Linda L-Y Wu; Robert J Norman; Rebecca L Robker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproduction, fertility, and development Volume: 24 ISSN: 1031-3613 ISO Abbreviation: Reprod. Fertil. Dev. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-03-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907465 Medline TA: Reprod Fertil Dev Country: Australia |
Other Details:
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Languages: eng Pagination: 29-34 Citation Subset: IM |
Affiliation:
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The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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