| The impact of murine intestinal apolipoprotein A-IV expression on regional lipid absorption, gene expression, and growth. | |
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MedLine Citation:
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PMID: 21840868 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Apolipoprotein A-IV (apo A-IV) is synthesized by intestinal enterocytes during lipid absorption and secreted into lymph on the surface of nascent chylomicrons. A compelling body of evidence supports a central role of apo A-IV in facilitating intestinal lipid absorption and in regulating satiety, yet a longstanding conundrum is that no abnormalities in fat absorption, feeding behavior, or weight gain were observed in chow-fed apo A-IV knock-out (A4KO) mice. Herein we reevaluated the impact of apo A-IV expression in C57BL6 and A4KO mice fed a high fat diet. Fat balance and lymph cannulation studies found no effect of intestinal apo A-IV gene expression on the efficiency of fatty acid absorption, but gut sac transport studies revealed that apo A-IV differentially modulates lipid transport and the number and size of secreted triglyceride-rich lipoproteins in different anatomic regions of the small bowel. Apo A-IV gene deletion increased expression of other genes involved in chylomicron assembly, impaired the ability of A4KO mice to gain weight and increase adipose tissue mass, and increased the distal gut hormone response to a high at diet. Together these findings suggest that apo A-IV may play a unique role in integrating feeding behavior, intestinal lipid absorption, and energy storage. |
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Authors:
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Trang Simon; Victoria R Cook; Anuradha Rao; Richard B Weinberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-12 |
Journal Detail:
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Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Wake Forest School of Medicine, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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