| The impact of meloxicam on postsurgical stress associated with cautery dehorning. | |
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MedLine Citation:
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PMID: 19164664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objectives were to determine the duration of the stress response associated with cautery dehorning and to assess the effectiveness of the nonsteroidal anti-inflammatory drug meloxicam (Metacam, 20 mg/mL solution for injection) for reducing that response. Sixty Holstein heifer calves were blocked by age and randomly assigned to receive an i.m. injection of meloxicam or a placebo (0.5 mg/kg). All calves were given a lidocaine cornual nerve block delivered 5 mL per side 10 min before dehorning. To establish baseline values, calves were sham dehorned 24 h before actual dehorning. Blood samples were taken via indwelling jugular catheters at 0, 0.5, 1, 1.5, 2, 4, 6, and 24 h after the procedure. Heart and respiratory rates were also taken at these times. Data were analyzed using PROC MIXED in SAS. Analysis of covariance was employed to assess the difference between sham and dehorning at each time period. Dehorning was associated with elevated serum cortisol (d -1: 33.9 +/- 1.26; d 0: 46.2 +/- 2.33 nmol/L) and heart rate (d -1: 108 +/- 1.8; d 0: 109.4 +/- 2.4 beats per minute) in both groups for 24 h, and elevated respiratory rate (sham: 42.2 +/- 1.95 vs. dehorning: 45.1 +/- 2.19 respirations per minute) in both groups for 6 h. A treatment x time interaction was found for cortisol, with meloxicam calves having lower serum cortisol than controls until 6 h after dehorning (meloxicam: 49.7 +/- 4.37 vs. control: 63.0 +/- 6.94 nmol/L). There was no difference between the treatment groups at 24 h (meloxicam: 35.2 +/- 2.74 and control: 34.8 +/- 3.64 nmol/L of cortisol). Overall, the changes in heart rates (increase meloxicam: 3.74 +/- 0.96 vs. control: 4.70 +/- 1.87) and respiratory rates (increase meloxicam: 2 +/- 0.1 vs. control: 4 +/- 0.2) were greater in the control group compared with the meloxicam group. These results indicate that meloxicam reduced the physiological stress response to dehorning. |
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Authors:
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A Heinrich; T F Duffield; K D Lissemore; E J Squires; S T Millman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of dairy science Volume: 92 ISSN: 1525-3198 ISO Abbreviation: J. Dairy Sci. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-02-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985126R Medline TA: J Dairy Sci Country: United States |
Other Details:
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Languages: eng Pagination: 540-7 Citation Subset: IM |
Affiliation:
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Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacology* Cattle / physiology* Cautery / adverse effects, veterinary* Female Heart Rate / drug effects Horns / surgery* Hydrocortisone / blood Random Allocation Respiration / drug effects Stress, Physiological / drug effects* Thiazines / administration & dosage, pharmacology* Thiazoles / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Thiazines; 0/Thiazoles; 50-23-7/Hydrocortisone; 71125-38-7/meloxicam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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