Document Detail


The impact of maternal body mass on the effectiveness of 17 alpha-hydroxyprogesterone caproate.
MedLine Citation:
PMID:  18839818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the impact of maternal prepregnancy body mass index (BMI) on rates of recurrent preterm delivery (PTD) in women receiving 17alpha-hydroxyprogesterone caproate (17P) prophylaxis. STUDY DESIGN: The study population was identified from a large perinatal database containing prospectively collected information from women at high risk for PTD. We included patients with a current singleton pregnancy and a history of PTD who received weekly nursing visits and 17P 250 mg intramuscular injections beginning at 16.0 to 20.9 weeks' gestation. The data were stratified by number of prior PTDs (1 or >1) and maternal prepregnancy BMI (lean, normal, overweight and obese). Primary study outcomes included the rates of recurrent PTD at <35 and 32 weeks' gestation, and pregnancy loss at <24 weeks' gestation. RESULTS: Delivery outcomes for 606 women receiving 17P were analyzed. There were no significant differences found in the incidence of preterm labor, the rates of recurrent PTD or pregnancy loss at <35, 32 or 24 weeks between the BMI groups. CONCLUSION: Maternal prepregnancy BMI does not appear to influence the rates of recurrent PTD in women with singleton gestation receiving 17P prophylaxis. Larger studies are needed to confirm our findings.
Authors:
Gary Ventolini; Janice Duke; William Po; Sheela Barhan; Debbie Rhea; Cheryl Desch; Niki Istwan; Gary Stanziano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  53     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  667-71     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Wright State University, Dayton, Ohio 45409, USA. gary.ventolini@wright.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index*
Female
Humans
Hydroxyprogesterones / therapeutic use*
Pregnancy
Premature Birth / prevention & control*
Prospective Studies
Recurrence / prevention & control
Tocolytic Agents / therapeutic use*
Young Adult
Chemical
Reg. No./Substance:
0/Hydroxyprogesterones; 0/Tocolytic Agents; 630-56-8/17-alpha-hydroxy-progesterone caproate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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