Document Detail


The impact of macular pigment augmentation on visual performance in normal subjects: COMPASS.
MedLine Citation:
PMID:  21237188     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study was conducted to investigate whether augmentation of macular pigment (MP) enhances visual performance (VP). 121 normal subjects were recruited. The active (A) group consumed 12mg of lutein (L) and 1mg of zeaxanthin (Z) daily. MP optical density (MPOD) was assessed by customized heterochromatic flicker photometry. VP was assessed as best corrected visual acuity (BCVA), mesopic and photopic contrast sensitivity (CS), glare disability, photostress, and subjective visual function. Subjects were assessed at baseline; 3; 6; 12months (V1, V2, V3 and V4, respectively). Central MPOD increased significantly in the A group (p<0.05) but not in the placebo group (p>0.05). This statistically significant increase in MPOD in the A group was not, in general, associated with a corresponding improvement in VP (p>0.05, for all variables), with the exception of a statistically significant time/treatment effect in "daily tasks comparative analysis" (p=0.03). At V4, we report statistically significant differences in mesopic CS at 20.7cpd, mesopic CS at 1.5cpd under high glare conditions, and light/dark adaptation comparative analysis between the lower and the upper MP tertile groups (p<0.05) Further study into the relationship between MP and VP is warranted, with particular attention directed towards individuals with low MP and suboptimal VP.
Authors:
John M Nolan; James Loughman; Mukunda C Akkali; Jim Stack; Grainne Scanlon; Peter Davison; Stephen Beatty
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-13
Journal Detail:
Title:  Vision research     Volume:  -     ISSN:  1878-5646     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417402     Medline TA:  Vision Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Macular Pigment Research Group, Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
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