| The impact in the agnors expression and apoptosis in the prostate of hamster-mesocricetus auratus (HMA) submitted to finasteride application. | |
| | |
MedLine Citation:
|
PMID: 22124645 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the impact on the AgNORs expression and apoptosis in the prostate of the hamster-Mesocricetus auratus (HMA) submitted to the application of finasteride. METHODS: Twenty male rodents of the species HMA (n = 20) were randomly assigned to groups of ten animals: Finasteride group (n = 10) and the Control group (n = 10). In the finasteride group 7.14 ng / mL finasteride was subcutaneously (SC) administered on the back of the animals three times a week for 90 days. AgNOR expression was evaluated as a marker of cell proliferation and apoptosis as a marker of cell death. RESULTS: The expression of AgNORs was lower in the finasteride group, 2.846 ± 0.877 vs. 3.68 ± 1.07 argyrophilic regions per square micrometer (µm2) in the control group, p = <0.0001. Apoptosis was more frequent in the finasteride group, 53.62 ± 1.389 versus 14.76 ± 2.13 per µm2 in the control group, p = 0.0408. CONCLUSION: We observed decreased expression of AgNORs and promotion of apoptosis in the prostate of rodents treated with finasteride. |
| | |
Authors:
|
Dimas José Araújo Vidigal; Alcino Lázaro da Silva; Felipe Eduardo Costa Vidigal |
Related Documents
:
|
2855875 - Human retroviruses and herpes viruses: their role in immune dysfunctions and neoplasia. 20153075 - Minocycline differentially modulates macrophage mediated peripheral immune response fol... 19004945 - African swine fever virus blocks the host cell antiviral inflammatory response through ... 5943935 - Leukocytes and interferon in the host response to viral infections. ii. enhanced interf... 22381405 - The effects of the stress response on immune function in invertebrates: an evolutionary... 12527335 - Apoptosis and traf-1 cleavage in epstein-barr virus-positive nasopharyngeal carcinoma c... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Revista do Colegio Brasileiro de Cirurgioes Volume: 38 ISSN: 1809-4546 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7809515 Medline TA: Rev Col Bras Cir Country: - |
Other Details:
|
Languages: ENG; POR Pagination: 334-337 Citation Subset: - |
Affiliation:
|
Faculdade de Medicina, UFMG, MG, BR. |
Vernacular Title:
|
O impacto na expressão agnors e apoptose na próstata do hamster-mesocricetus auratus (HMA) submetido à aplicação de finasterida. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of depressive symptoms in people with diabetes mellitus and foot ulcers.
Next Document: Anatomic study of the double-bundle of the anterior cruciate ligament with the knee in 90º flexion.