Document Detail

The impact of the human immunodeficiency virus type 1 on the management of severe malnutrition in Malawi.
MedLine Citation:
PMID:  10824214     Owner:  NLM     Status:  MEDLINE    
A study was undertaken in a central nutritional rehabilitation unit in southern Malawi to assess the impact of HIV infection on clinical presentation and case fatality rate. HIV seroprevalence in 250 severely malnourished children over 1 year of age was 34.4% and overall mortality was 28%. HIV infection was associated significantly more frequently with marasmus (62.2%) than with kwashiorkor (21.7%) (p < 0.0001). Breastfed children presenting with severe malnutrition were significantly more likely to be HIV-seropositive (p < 0.001). Clinical and radiological features were generally not helpful in distinguishing HIV-seropositive from HIV-seronegative children. The case fatality rate was significantly higher for HIV-seropositive children (RR 1.6 [95% CI 1.14-2.24]). The increasing difficulties of managing the growing impact of HIV infection on severely malnourished children in Malawi are discussed in the context of reduced support for nutritional rehabilitation units.
L Kessler; H Daley; G Malenga; S Graham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  20     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-06-14     Completed Date:  2000-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM; X    
Department of Paediatrics, College of Medicine, Blantyre, Malawi.
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MeSH Terms
Child, Preschool
HIV Seropositivity / complications*,  mortality
HIV Seroprevalence
HIV-1 / immunology*
Kwashiorkor / mortality,  therapy,  virology
Malawi / epidemiology
Protein-Energy Malnutrition / mortality,  therapy,  virology*
Survival Rate

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