Document Detail


The impact of hepatic steatosis on liver regeneration after partial hepatectomy.
MedLine Citation:
PMID:  23311417     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND & AIM: Experimental studies in animals have suggested that liver regeneration is impaired in steatotic livers. However, few studies have focused on the impact of steatosis in patients undergoing partial hepatectomy (PH). This study aims to determine the role of steatosis on liver regeneration in humans following PH. METHODS: Eighty-eight patients undergoing PH were included in this study. All patients underwent CT-scanning of the liver preoperatively and 7 days after surgery. Additional CT-scans were performed 6 months post-operatively. Preoperative and post-operative volumes of the total liver (TLV), future liver remnant (FLR) and liver remnant (LR) were measured on CT-scans. Regeneration indices (RI) were calculated at 7 days and 6 months using the formula: (Volume LR-Volume FLR)/Volume FLR × 100%. Based on histological examination of the resected part of the liver, patients were classified into three groups: (1) no steatosis, (2) mild steatosis (1-29%) and (3) moderate-to-severe steatosis (≥30%). RESULTS: The early RI (at day 7) was 40%, 24% and 20% for patients in group 1, 2 and 3 respectively. Late RI (at 6 months) was 81% for group 1, 44% for group 2 and 22% for group 3 (P = 0.019). At 7 days, the LR represented 79%, 80% and 79% of the TLV for groups 1-3. At 6 months, this was 93%, 92% and 79% respectively. CONCLUSION: Although early RI after PH did not differ in patients with or without steatosis, the late RI in patients with moderate-to-severe steatosis was lower, suggesting that late liver regeneration is impaired in these patients.
Authors:
Petra G Kele; Eric J van der Jagt; Annette S H Gouw; Ton Lisman; Robert J Porte; Marieke T de Boer
Related Documents :
15774247 - Laparoscopic nephron sparing surgery: evolution in a decade.
11012907 - A modern approach to selectivity of proteinuria and tubulointerstitial damage in nephro...
24618607 - Squamous neoplasia of the scrotum: a series of 29 cases.
6225747 - Renal artery stenosis and evaluation of the effect of endoluminal dilatation. compariso...
12854107 - Recommendations for screening intervals for small aortic aneurysms.
3515737 - Treatment of bacterial prostatitis. comparison of cephalexin and minocycline.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-12
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  -     ISSN:  1478-3231     ISO Abbreviation:  Liver Int.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Progress in the Synthesis of Canthine Alkaloids and Ring-Truncated Congeners.
Next Document:  An analysis of online messages about probiotics.