| The impact of hepatic pressurization on liver shear wave speed estimates in constrained versus unconstrained conditions. | |
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MedLine Citation:
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PMID: 22170769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased hepatic venous pressure can be observed in patients with advanced liver disease and congestive heart failure. This elevated portal pressure also leads to variation in acoustic radiation-force-derived shear wave-based liver stiffness estimates. These changes in stiffness metrics with hepatic interstitial pressure may confound stiffness-based predictions of liver fibrosis stage. The underlying mechanism for this observed stiffening behavior with pressurization is not well understood and is not explained with commonly used linear elastic mechanical models. An experiment was designed to determine whether the stiffness increase exhibited with hepatic pressurization results from a strain-dependent hyperelastic behavior. Six excised canine livers were subjected to variations in interstitial pressure through cannulation of the portal vein and closure of the hepatic artery and hepatic vein under constrained conditions (in which the liver was not free to expand) and unconstrained conditions. Radiation-force-derived shear wave speed estimates were obtained and correlated with pressure. Estimates of hepatic shear stiffness increased with changes in interstitial pressure over a physiologically relevant range of pressures (0-35 mmHg) from 1.5 to 3.5 m s(-1). These increases were observed only under conditions in which the liver was free to expand while pressurized. This behavior is consistent with hyperelastic nonlinear material models that could be used in the future to explore methods for estimating hepatic interstitial pressure noninvasively. |
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Authors:
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V Rotemberg; M Palmeri; R Nightingale; N Rouze; K Nightingale |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-14 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 57 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-05 Completed Date: 2012-04-19 Revised Date: 2012-05-10 |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 329-41 Citation Subset: IM |
Affiliation:
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Duke University, Durham, NC 27708, USA. veronica.rotemberg@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Dogs Elasticity Liver / pathology*, physiopathology* Liver Diseases / pathology, physiopathology Mechanical Processes* Organ Size Venous Pressure |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA-142824/CA/NCI NIH HHS; R01 CA142824/CA/NCI NIH HHS; R01 EB-002132/EB/NIBIB NIH HHS; R01 EB002132/EB/NIBIB NIH HHS; T32 GM007171/GM/NIGMS NIH HHS; T32 GM007171/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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