Document Detail


The impact of hepatic portoenterostomy on liver transplantation for the treatment of biliary atresia: Early failure adversely affects outcome.
MedLine Citation:
PMID:  22463739     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Alexopoulos SP, Merrill M, Kin C, Matsuoka L, Dorey F, Concepcion W, Esquivel C, Bonham A. The impact of hepatic portoenterostomy on liver transplantation for the treatment of biliary atresia: Early failure adversely affects outcome. Abstract:  The most common indication for pediatric LTx is biliary atresia with failed HPE, yet the effect of previous HPE on the outcome after LTx has not been well characterized. We retrospectively reviewed a single-center experience with 134 consecutive pediatric liver transplants for the treatment of biliary atresia from 1 May 1995 to 28 April 2008. Of 134 patients, 22 underwent LTx without prior HPE (NPE), while 112 patients underwent HPE first. HPE patients were grouped into EF, defined as need for LTx within the first year of life, and LF, defined as need for LTx beyond the first year of life. NPE and EF groups differed significantly from the LF group in age, weight, PELD, and ICU status (p < 0.05) with NPE having the highest PELD and ICU status. Patients who underwent salvage LTx after EF following HPE had a significantly higher incidence of post-operative bacteremia and septicemia (p < 0.05), and subsequently lower survival rates. One-year patient survival and graft survival were as follows: NPE 100%, EF 81%, and LF 96% (p < 0.05); and NPE 96%, EF 79%, and LF 96% (p < 0.05). Further investigation into the optimal treatment of biliary atresia should focus on identifying patients at high risk of EF who may benefit from proceeding directly to LTx given the increased risk of post-LTx bacteremia, sepsis, and death after failed HPE.
Authors:
Sophoclis P Alexopoulos; Melanie Merrill; Cindy Kin; Lea Matsuoka; Fred Dorey; Waldo Concepcion; Carlos Esquivel; Andrew Bonham
Related Documents :
17984429 - The use of nocturnal home hemodialysis as salvage therapy for patients experiencing per...
22654459 - Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompe...
17697909 - Prospective evaluation of patient-reported outcomes during treatment with deferasirox o...
9223689 - Comparative efficacy of hemodialysis and hemoperfusion in severe theophylline intoxicat...
9456479 - Peritoneal dialysis. an adjunct to pediatric postcardiotomy fluid management.
22772739 - Optimal time for restoring the reliability of liver stiffness measurement in patients w...
21420069 - Redistribution of gastric blood flow by embolization of gastric arteries before esophag...
22519849 - Comparison of the antitussive effect of remifentanil during recovery from propofol and ...
22130319 - In vivo optical coherence tomography of very late drug-eluting stent thrombosis compare...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-30
Journal Detail:
Title:  Pediatric transplantation     Volume:  -     ISSN:  1399-3046     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802574     Medline TA:  Pediatr Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Surgery, University of Southern California, Los Angeles Department of Surgery, Stanford University, Palo Alto Department of Biostatistics, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen...
Next Document:  The role of stem cells in muscular dystrophies.